Using Clostridium aerosols to convert one-carbon gas to efficiently synthesize medium and long-chain chemicals

The green sustainable manufacturing model is an important way to achieve China's "carbon peak and carbon neutral" strategic goals

In this study, based on the high-efficiency molecular technology platform of Clostridium aerophages established in the early stage, the researchers first introduced a heterologous synthesis pathway into Clostridium Jondalae, opening up the conversion path of synthesis gas to isopropanol, and through this pathway The optimization of the gene expression level and copy number in the medium has gradually improved the isopropanol synthesis ability of the strain

The above research results reveal the metabolic characteristics and application potential of Clostridium aerobatics using one-carbon gas to synthesize high-value chemicals, providing a reference for the creation of a diversified cell factory for this important industrial microorganism, and promoting the industrial application of C1 biotransformation technology Process

Doctoral student Jia Dechen of the Center for Molecular Plant Excellence is the first author of the paper, and researcher Gu Yang is the corresponding author of the paper

Link to the paper: https://doi.

High-value utilization of carbon dioxide/carbon monoxide gas based on microbial conversion

The engineered bacteria of Clostridium jodalarius uses synthesis gas to produce isopropanol, 3-hydroxybutyric acid and ethanol