Using Languang mfy-01 sealing tester to monitor the sealing performance of blister packaging

Abstract: Blister packaging is a kind of packaging form formed by the heat sealing process of plastic hard film and medical aluminum foil The sealing performance of blister packaging is a very important performance index, which has an important impact on the quality of packaged drugs In this paper, mfy-01 sealing tester developed by Jinan Languang mechanical and Electrical Technology Co., Ltd is used to test the sealing performance of blister packaging, and the testing principle of the equipment is introduced, and the basic process of the test is described, so as to provide reference for the enterprise to monitor the sealing performance of blister packaging Key words: Blister packaging, blister packaging, PTP packaging, medicine, sealing performance, sealing tester, air leakage, bubble 1, meaning with the survival of the fittest in the form of drug packaging, blister packaging has become an important part of the current drug packaging market with its advantages of good protection, convenient use, light quality, etc Blister packaging, also known as blister packaging and PTP packaging, mainly consists of two parts, namely, plastic hard disk with blister eye and medical aluminum foil During packaging, the medicine is put into the blister eyes of the hard film, and then it is heat sealed with the medical aluminum foil, thus forming a blister packaging with independent blister eyes Because the damage of one blister hole in blister packaging will not affect the integrity of other blisters, the integrity of each blister hole is particularly important If the sealing performance of blister packaging is poor, water vapor, oxygen and other gases in the external environment will penetrate into the packaging along the poor sealing position, causing the drug deliquescence, discoloration and other phenomena Figure 1 Blister packaging 2 At present, the sealing performance test mainly refers to GB / T 15171-1994 test method for sealing performance of soft package, which is applicable to the sealing performance test of sealing soft package made of various materials 3 The test sample was packaged with blister 4 In this paper, Labthink blue light mfy-01 sealing tester is used to test the sealing performance of blister packaging samples Fig 2 test principle of mfy-01 sealing tester this equipment is developed by using the principle of differential pressure test During the test, the sample is placed in the water of the sealed tank By vacuuming the inside of the sealed tank, the pressure difference between the inside and the outside of the sample immersed in the water will be generated If the sealing of the sample is poor, under the effect of the pressure difference, the gas inside the sample will overflow to the outside along the weak sealing position of the sample surface In the water, there are continuous bubbles on the sample surface, or by observing the sample expansion and release After vacuum, the shape of the sample is restored, and the sealing performance of the sample is judged 4.2 scope of application this equipment is applicable to the sealing performance test of packaging bags, bottles, tubes, cans, boxes, etc in food, pharmaceutical, medical equipment, daily chemical, automobile, electronic components, stationery and other industries, including glass, plastic, metal materials, etc It is applicable to the test of the sealing performance of the sample after the drop and pressure test This equipment conforms to many national and international standards, such as GB / T 15171, ASTM d3078, etc 4.3 the vacuum degree of equipment parameter is 0-90 kPa There are three kinds of effective dimensions for the vacuum chamber: 270 mm (diameter) × 210 mm (height), 360 mm (diameter) × 585 mm (height) and 460 mm (diameter) × 330 mm (height) The system adopts digital preset test vacuum degree and vacuum holding time to ensure the accuracy of test data Automatic constant pressure air supply technology further ensures that the test can be carried out under the preset vacuum conditions The professional software supports the functions of automatic back blow unloading and automatic end of test to ensure the smooth test process 5 Test step (1) immerse the blister package sample in the water of the sealed tank (2) Close the sealing cover to ensure that there is no air leakage around the sealing cover and the sealing tank is well sealed Through the microcomputer operation interface, the vacuum degree and the pressure holding time in the vacuum tank are set (3) Open the vacuum pump, click the test key on the operation panel, and the test starts (4) Observe the bubbles on the sample surface during vacuumizing and pressure maintaining If there are continuous bubbles on the surface of the sample, record the pressure value and the position of bubbles If there are no continuous bubbles, it indicates that the sample is well sealed under the set pressure Fig 3 test phenomena bubble generation 6 Test results five bubble cap packaging samples were tested in this test, and five of them were leaking Four of them were leaking at the heat sealing edge, with the pressure of - 31.5kpa, - 70.0kpa, - 26.9kpa, - 43.1kpa respectively The other sample was at Zui large negative pressure of - 90kpa There is no air leakage and it has good sealing performance 7 Conclusion sealing performance is an important performance of blister packaging Mfy-01 sealing tester is a professional testing equipment used to test the sealing performance of blister packaging It can not only carry out quantitative analysis on the sealing performance of packaging, but also provide the basis for the improvement of packaging technology through the qualitative analysis on the position of air leakage In order to overcome the disadvantages of the traditional sealing tester, such as heavy workload of manually recording test results, the risk of recording errors, the difficulty of data storage, difficult to consult, and poor traceability, Labthink blue light developed i-process 6200 on the basis of mfy-01 sealing tester Sealing tester and data processing system, the system is specialized in the detection of sealing performance of products on the production site, which can automatically judge whether the test results are qualified or not, and the test data can be automatically uploaded to the data management center for data management and storage, so as to facilitate the management and control of the sealing performance of products on the production site Fig 4 in addition to the sealing performance of i-process6200 sealing tester and data processing system, the heat sealing strength, water vapor transmittance, oxygen transmittance and other performance of blister packaging will also have an important impact on the quality of the packaged drugs For the corresponding testing equipment, you can log in to Languang company to check or call for consultation The more you understand, the more you trust! Labthink is looking forward to enhancing technical exchanges and cooperation with enterprises and institutions in the industry!