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Cartilage acts as a shock absorber in the joints, but it is easily damaged by daily wear and tear or sports injuries and falls
.
The current gold standard surgical method using chondrocytes to repair damaged cartilage areas has not been completely successful
Scientists at the Center for Human Development, Stem Cell and Regeneration think they may have the answer
.
They successfully differentiated embryonic stem cells into chondrocytes in the laboratory, and then used these cells to generate three-dimensional cartilage tissue without any synthetic or natural support materials
Researchers used scaffold-free technology to generate cartilage tissue for the first time
.
The scale of cartilage tissue exceeds 1 mm without affecting its structure and mechanical properties .
The research team hopes that after more research, the tissue created in this laboratory can eventually be routinely used in surgery to repair damaged cartilage
This interdisciplinary study was published in the journal Scientific Reports and was led by Dr.
Francesca Horton and Dr.
Rahul Tare from the University of Southampton School of Medicine
.
Dr.
Horton said: "This research is exciting because we can generate cartilage with properties similar to normal human cartilage, which has the potential to provide a powerful tissue engineering product for cartilage repair
.
"
Dr.
Talay added: "This tissue-based alternative to the'similar' method has the potential to constitute a phased improvement in the current cell-based repair of damaged cartilage and improve long-term patients.
Prognosis
.
"
Reference: "A scaffold-free approach to cartilage tissue generation using human embryonic stem cells" by Lauren A.
Griffith, Katherine M.
Arnold, Bram G.
Sengers, Rahul S.
Tare and Franchesca D.
Houghton, 28 September 2021, Scientific Reports.
DOI: 10.
1038/s41598-021-97934-9
