Vasc Health Risk Managing: Periodontitis can be a risk factor for stroke, especially ischemic stroke.

This systematic review and meta-analysis investigates the relationship between periodontitis and stroke, and the results have been published online in Asc Health Risk Managing.
review follows the methodology established by the Guidelines for Systematic Overview and Meta-Analysis Preferred Reporting Projects (PRISMA).
is retrieved from five databases and two gray literature sources.
conducted a bias risk assessment after filtering the article.
three meta-analyses were carried out.
overall association between stroke and periodontitis in the case control study, ischemic stroke and periodontitis in the case control study, and the association between stroke and periodontitis in the queue study.
use the I2 index to evaluate heterogeneity and calculate the odds ratio (P 0.05).
the level of evidence by applying the Recommendation Assessment, Development, and Evaluation Rating (GRADE).
researchers screened 2,193 potentially relevant studies, 10 of which were qualitative and quantitative.
all articles are considered low-risk bias and low-level certainty.
results showed a positive correlation between the two diseases and an increased risk of stroke in the queue study (RR 1.88 (1.55, 2.29), P.lt;0.00001, I2=0%)) In case-controlled studies, the two diseases were positively associated with ischemic stroke events (RR 2.72 (2.00, 3.71), P.lt;0.00001, I2=4%).
, the results suggest that periodontitis may be a risk factor for stroke, especially in ischemic stroke.
, however, in order to draw reliable conclusions, it is necessary to carry out new research with excellent design.
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