VCAM1: A protein antibody that fights the bad effects of old blood and anti-aging.

Recently, the New Scientist website published a report entitled "Antibody can snobs from the age of the old blood".
article suggests that older blood can have a powerful effect on organ damage and aging.
, however, scientists from Stanford University have discovered an antibody that fights the "bad effects" of older blood and prevents the brains of mice from aging. the effects of
blood on aging were first discovered in an experiment that allowed young and elderly mice to share blood circulation.
study found that older mice appeared to benefit from this "arrangement" to develop healthier organs from age-related diseases.
, however, the aging of young mice was earlier.
these tests have shown that young blood can help restore health, while something in the blood in old age is harmful.
in this new development, researchers identified a protein that causes "harmfulness" in older blood and found a way to block its effects.
specifically, Hanadie Yousef of Stanford University found that the amount of protein in the blood called VCAM1 increases with age.
the level of the protein was 30 percent higher in people over 65 than in those younger than 25.
to detect the effects of VCAM1, Yousef injected the plasma of older mice into young mice.
found that young mice showed signs of aging: more inflammation in the brain and fewer new brain cells.
the plasma in older adults also had the same effect on young mice.
when Yousef injected the plasma of an elderly (in their late 60s) into a three-month-old mouse (in humans, about 20 years old), the mice's brains also showed signs of aging.
later, the researchers found that mice were protected from the "hazards" of older blood when they were injected before or at the same time with an antibody compound that blocks VCAM1.
Yousef presented her findings at the Society for Neuroscience's annual meeting last year. "If we can understand the mechanisms of aging and find ways to reverse it, it will promote healthy aging,"
.
," she said.
currently, Yousef is patenting the compound.
added: "Some teams have injected plasma from young donors into older people to see if this approach can improve health.
but, I think, I also need the destructive effects of middle and old blood. Jonathan Godbout of Ohio State University,
, said he hopes to see more data from the study and is cautiously optimistic that the work could lead to treatments that protect aging brains. Miles Herkenham, of the
National Institute sunder, said it was surprising that individual proteins had such an impact.
but these results need to be repeated by other laboratories.
Source: Decoding Medicine.