Viagra may be used for blood cancer treatment Single oral comparable Neupogen injection for 4 days

Typically, transplant practitioners use the standard granulocytic cell set stimulation factor (G-CSF), known as Amgen's Neupogen, to mobilize stem cellsThe UCSC team found that combining Viagra with Sanofi's stem cell mobilization agent Mozobil was equally effective in mobilizing hematopoietic stem cells: a fast 2-hour program consisting of Viagra and Mozobil was able to efficiently mobilize hematopoietic stem cells at a level comparable to the standard-care G-CSF five-day programthe study was published recently in the journal Stem Cell Reports"Both drugs are FDA-approved and can be tested in human volunteers relatively quickly," said author Camilla ForsbergIf successful, a new strategy will be offered for hematopoietic stem cell transplantationAlthough G-CSF drugs are effective in most donors, they require several days of administration before collecting hematopoietic stem cells, are expensive, and can cause side effects such as fatigue, nausea and bone painprevious research byCamilla Forsberg's lab has shown that increasing the ability of blood vessel walls to allow molecules to pass through blood vessels - vascular permeability - helps hematopoietic stem cells escape from bone marrow to the bloodstreamAs a result, the team speculated that the drug Viagra, which relaxes the walls of blood vessels, could promote stem cell mobilizationAfter all, the drug was originally designed to treat cardiovascular disease and was sometimes used to treat pulmonary hypertensionstudies found that in mice, a single oral Viagra and a single injection of Mozobil induced about 2,500 hematopoietic stem cells into the bloodstream within two hours, a 7.5-fold increase over the control groupBy contrast, Viagra alone is ineffective, while Mozobil alone shows about three times as much growthAlthough taking Viagra orally for three days is slightly better, the researchers believe that taking Viagra alone is comparable to Neupogen, which requires at least four days of injectionsthen, the researchers transplanted the harvested stem cells into other miceTransplanted animals that received hematopoietic stem cells from Viagra-Mozobil showed better functional, pluripotent stem cell transplants than transplanted animals that received hematopoietic stem cells from Mozobil alone, the study reportedViagra combined with AMD3100 to quickly and effectively mobilize functional HSCViagra, known as the "Little Blue Pill," has been used in the United States to treat ED for 20 years, and scientists are still working tirelessly to find potential new uses for the drug Researchers at the University of Manchester recently found that the ED drug Lilly Cialis, which belongs to the same class of PDE5 inhibitors as Viagra, slowed the progression of heart failure in sheep models In a study published in 2018, scientists at the Ottawa Hospital Institute showed that the combination of Viagra or Cialis and Seqirus' flu vaccine, Agriflu, significantly reduced the risk of postoperative cancer spreading in mice The team found that PDE5 inhibitors block myeloid inhibitorcells, which in turn allows naturally killing cells to target metastatic cancer cells in the latest developments in the ReDO (Oncology Drug Reuse) project, researchers have also found a range of mechanisms for the role of PDE5 drugs that may complement other drugs that treat cancer, including incurable glioblastomas now, Camilla Forsberg and her colleagues plan to work with clinicians to advance their current findings into human research, hoping that Viagra and Mozobil will provide a more attractive, affordable, one-day solution to the mobilization of hematopoietic stem cells than G-CSF reference source: 1, How Viagra can boost a widely used blood cancer 2, Viagra EnableS Efficient, Single-Day Hematopoietic Stem Cell Cell Cell Cell