Character Biography
Character Biography Wang meter autumn, born in 1981, Ruijin Hospital, Shanghai Jiaotong University School of Medicine researcher, Ph.
Academician extreme By September this year, Wang Jiqiu was exactly 40 years old
Few people know that this young doctor who has been "opening up" all the way has met "anxiety" head-on from the beginning of medicine
Academician Dean "Deadly hit" obesity, discovered the switch gene for beige fat
"Deadly hit" obesity, discovered the switch gene for beige fat When interviewing Wang Jiqiu, two words cannot be avoided-fat
In his memory, this segment is still unforgettable
In this direction, Wang Jiqiu has already explored
In order to clarify the pathogenesis, he established a gene knockout animal model.
Coincidentally, earlier than Wang Jiqiu’s research team, the top international journal "Nature" published a deep sequencing of 200,000 people in Iceland, and discovered multiple individuals with inactivating mutations in the LGR4 gene, showing a mouse model with a defect.
"On the track of scientific discovery, various research groups around the world are catching up with me , playing the speed of life and death, but they remind and verify each other to promote scientific development
academician In the following 10 years of clinical and scientific research work, Wang Jiqiu continued to explore this path and worked hard to pay off.
After 16 years of persistence, from following his mentor to leading his students as a mentor, he gradually drew a clear and definite path of obesity
Looking for "little fat guys" to create the world's largest adolescent obesity cohort
Looking for "little fat guys" to create the world's largest adolescent obesity cohort When it comes to obesity, especially the major health hazards of obesity in adolescents, it is almost common sense nowadays that women and children know it
The fate of Wang Jiqiu and LGR4 also began
How to find "Little Fat Dun"? The problem began, Wang Jiqiu insisted on strict entry criteria: body mass index (BMI)> 30 kg/m2, and the age is less than 30 years old
extreme Find one, just study one! Wang Jiqiu led the team to build the GOCY cohort from the initial preservation of patient blood samples and the establishment of a sample bank, to the later establishment of the world’s largest "human metabolism chamber" group, to measure the activity and basal metabolic rate of beige fat in the human body, an obesity with in-depth and fine phenotypic information The metabolic platform was built
In this way, the sporadic isolated cases of "little fat piercing" were divided into subgroups by Wang Jiqiu: primary obesity, syndrome obesity, secondary obesity.
.
.
He made a more detailed analysis of primary obesity.
Genetic typing
.
In 16 years, the GOCY cohort has now included more than 3,500 patients, making it the largest adolescent obesity cohort in the world
.
On this basis, Wang Jiqiu led a research team to cooperate with companies to identify a series of new obesity-causing gene mutations, and break a new model of transformational research on "rare cases-humanized mouse models-molecular mechanisms"
.
At present, the team has completed the identification of the pathogenic gene map of severely obese patients, and the relevant research will be published soon
.
This means that he can answer the questions asked by patients in the clinic one after another-"Why am I so fat?"
The essence of scientific research is exploration, and the essence of exploration is to dare to break into "no man's land"
The essence of scientific research is exploration, and the essence of exploration is to dare to break into "no man's land" Not satisfied with the status quo, Wang Jiqiu and his colleagues are still unremittingly looking for drugs that can promote white fat beige
.
In cooperation with his colleagues, he has discovered a traditional Chinese medicine monomer-berberine (ie berberine), which can significantly promote the beigeization of white fat, not only in mice, but also in weight loss patients.
Effect
.
In addition, the starting point of his scientific research road-LGR4 drug screening is also beginning to dawn
.
"From the patient, and finally back to the patient
.
" Wang Jiqiu always insisted on serving patients academically and solving the most prominent clinical problems
.
These jobs are like "no man's land" one by one, and there are no signs on this road
.
"Every scientific research work is an exploration.
You don’t know exactly which way will work.
Just
like walking in the dark, you will inevitably experience confusion, depression, and even panic
.
But if everyone walks along.
Where can the existing road be discovered and where scientific progress can be made?" Speaking of this, Wang Jiqiu's eyes flashed
.
In the eyes of tutor Ning Guang, Wang Jiqiu "is a person who breaks the casserole and asks the end", and scientific research requires this kind of spirit
.
"He continues to deepen around a gene, a pathway, and a disease, and he has achieved himself, and he has also cultivated his own students and teams
.
I believe he will have more results and become a leader in this field
.
" Academician Ning Guang is strict with students , Is full of expectations
.
academician Wang Jiqiu's research group has 30 members, with an average age of 30 years
.
This energetic team is making its goal more and more clear: to strive to become the world's top scientific research clinical center for obesity metabolism research
.
This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only.
This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of
the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed
description of the concern or complaint, to
service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content
will be removed immediately.
