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recently, the team of Wang Wei of the Department of Medical Bioinsyntics of Peking University's School of Basic Medicine, in collaboration with the Kang Wei team of the Beijing Genomics Institute of the Chinese Academy of Sciences, published an article in the journal
Science Advances
, "A quasi-paired cohort strategy reveals the granted detoxifying function of microbes in the gut of autistic children". Using macrogenomics techniques and matching analysis methods, they revealed the imbalance of intestinal bacteria in autistic patients, detoxifying dysfunction, which in turn leads to the accumulation of toxins and mitochondrial dysfunction in patients. Changes in the metabolic function of intestinal bacteria in autistic children may be involved in the pathogenesis of autism. The findings could provide new strategies for future autism interventions.October 22
Science Advances
published the team's findings on the autistic gut microbiomeAutism Spectrum Disorder (ASD) is a complex set of neurodevelopmental disorders characterized by impaired social function, repeated stereotypes, and narrow interests. Worldwide, the incidence of autism is on the rise, the U.S. Centers for Disease Control and Prevention this year released the U.S. 8-year-old autism prevalence rate of 1/54, the incidence of autism continues to rise. At present, the cause of autism is still unclear, environmental factors and genetic factors can cause the interaction of disease. Recent studies have shown that gut microbiotics play an important role in autism. Common gastrointestinal diseases are common in children with autism. At the same time, autistic children are very picky and lack certain digestive enzymes in the body, which inevitably changes the level of nutrients and bacterial metabolites, the symblotic bacteria have an impact on the planting, resulting in microbial disorders. In addition, many studies have found intestinal bacteria disorders in autistic children, such as reduced Bifidobacteria abundance, increased Thyrobacteria genus abundance, and intestinal bacteria disorders are thought to be associated with inflammation of the intestinal mucosa and increased intestinal permeability.macrogenomics based on bird gun sequencing is widely used to explore the relationship between microorganisms and hosts, as well as to look for disease pathogenesis in which microorganisms are involved. Macro genome sequencing provides higher species resolution and more comprehensive information on microbial function. However, gut microorganisms are affected by a variety of factors, such as genetics, age, diet and health, and even in healthy populations there is a great deal of heterogeneity in the microbiome. In addition, gut microbiomes are limited by complex metabolic networks. Based on these factors, Wang's team developed a new macro genome analysis strategy, class pairing analysis, which pairs autistic groups with similar metabolic backgrounds with control group individuals and converts the original groupings into boundary pairing groups. This method of analysis is similar to the study of twins in genomic analysis. This not only reduces individual heterogeneity, but also increases statistical efficacy.
Class pairing analysisThey sequenced 79 samples from the autistic and control groups, and applied a class pairing analysis strategy to the sequencing data to identify the metabolic path path paths of autistic-related bacteria. The analysis found significant deficiencies in the detoxifying enzymes and pathfages of the intestinal bacteria in autistic children, mainly involving glutathione (key antioxidants and detoxifying enzyme cofactors) and organic toxin degradation. The abundance of these detoxifying enzymes is negatively related to mitochondrial dysfunction markers, suggesting that the detoxification function of the bacteria has a potential protective effect on mitochondrials. Diagnostic models based on these enzymes can accurately distinguish between autistic and healthy control children (AUC 0.88), and diagnostic scores are associated with clinical scores for autism. Epidemiological studies have found that environmental toxin exposure is an important environmental factor for autism, and impaired intestinal detoxification in autistic children explains why patients are more sensitive to toxin exposure. The study found important new mechanisms for microbial involvement in the onset of autism and provided new strategies for medical interventions in autism.A There is a significant impairment of the detoxifying enzyme and detoxification pathline in children with autism, and the damage to the intestinal detoxification path in children with B ASD is significantly related to biomarkers of mitochondrial dysfunction Zhang Meng, a 2015 master's student at Peking University School of Basic Medicine, Dr. Chu Yanan of the Chinese Academy of Sciences, and Meng Qingren, a master's student, are co-authors of the paper.
Wang Wei, graduated from Concord Medical University of China in 2005 with a doctorate in medicine, lecturer in the Department of Medical Bioanynamics, Department of Basic Medicine, Peking University, from 2005 to 2011, associate professor in 2011 and an associate professor of autism in the Department of Medicine, Peking University The Secretary-General of the Research Center, who has long been engaged in biomedical research on autism systems, has published several papers in
Science Advances, Nucleic Research, Trends in Molecular Medicine, Briefings in Bioinformatics, Scientific Reports, Frontiers in Genetics
.