What about high blood lipids? - Cheesecella Zhang to help

With the continuous improvement of people's living standards and the change of Chinese diet structure, hyperlipidemia has become one of the important causes of harm to human health, its specific performance is mainly high cholesterol, hyperlipidemia and so on. According to the latest statistics, the number of abnormal blood lipids in China has exceeded 400 million people, and shows a trend of aging. In terms of prevention, the number of people who can control blood lipids is very small, which has aroused widespread concern. Animal experiments show that probiotics have a positive effect on the treatment of hyperlipidemia and can significantly reduce serum cholesterol and lipid levels., the first probiotic lactic acid bacteria in China to complete genome-wide sequencing, has been found to be effective in improving lipid metabolism.: 30 male ratswere selected and randomly divided into three groups (i.e., control group, hyperlipidemia group and probiotic group).control group: normal diet feeding daily.high-fat blood disorder group: daily high-fat diet, which induces hyperlipidemia, and 38-67 days also give high-fat diet and supplement 1mL of physiological saline.probiotic group: While maintaining the same diet as the hyperlipidemia group, add 1mL of physiological saline containing LC-Zhang (2x
10
8 CFU) on day 38-67.blood samples taken from each rat for 7, 37 and 67 days for serum analysis, and at the end of the experiment, liver samples from each rat were taken for DNA chip analysis.
Results 1. Blood sample analysis After 30 days of a high-fat diet, TC, TG, and LDL-C levels in rats in the hyperlipidemia and probiotic groups were found to increase significantly compared to the control group, and HDL-C levels decreased significantly (P<0.01), and the high-fat diet successfully induced hyperlipidemia in rats.TG and LDL-C levels in the serum decreased by 31.3% and 30.8% (P<0.01), respectively, compared with the hyperlipidemia group after eating the cheese cheese Zhang, while TC and TG levels in liver tissue decreased by 20.4% and 17.5% (P<05), respectively. Cheesecella Zhang can significantly improve the metabolism of hyperlipidemia, reduce the level of total cholesterol, triglycerides and other metabolic indicators, with good blood lipid reduction effect.Total Cholesterol (TC), Triglycerides (TG), HDL-C, and LDL Cholesterol (LDL-C) 2. Gene Expression AnalysisThere were significant differences in gene expression in liver tissue in rats in the probiotic group and hyperlipidemia group (P<0.05), and a total of 324 gene expressions were found in the probiotic group and 431 gene expressions were reduced. The modified genes are associated with multiple cellular processes, in particular the metabolism of lipids, homogenic acids and fatty acids, as well as the tissue and biology of the organocells, and the reduced genes are related to large molecule metabolism, biosynthesis processes, cell metabolism, and apoptosis.3. Differential gene expression associated with lipid metabolismA total of 22 upward genes and 8 downward genes were identified, which are related to fatty acid metabolism, mitochondrial fatty acid extension, biosynthetic of steroids, biosynthetics of bile acids, biosynthetics of glycelin phospholipids, biosynthetics of unsaturated fatty acids, and peanut tyrenne metabolism.
Cheesecella Zhang can control cholesterol and lipid levels by regulating differential gene expression associated with lipid metabolism. Among them, Cheesecella Zhang can raise the genes of fatty acid metabolism, thereby accelerating β-oxidation, reducing the level of free fatty acids, reducing the concentration of TG, and lowering the Ephx2 gene to control blood pressure levels.At the same time, cheese-lactobacillus Zhang can speed up intestinal digestion, increase the synthesis of bile acid genes, thereby increasing the secretion of bile acid, the liver cholesterol is distributed more into the bile, and speed up excretion to reduce the blood cholesterol content. Total knots Cheesecella Zhang can significantly improve hyperlipidemia and control levels of indicators such as total cholesterol, triglycerides, LDL cholesterol, and HDL cholesterol in the serum and liver. Through DNA chip technology analysis, it was found that cheesecella Zhang can change the expression of related lipid metabolism genes, accelerate the oxidation of fatty acids, control blood pressure and increase cholesterol loss to control lipid metabolism. for hyperlipidemia, Koto Bio has conducted and completed clinical trials of relevant probiotic preparations at Inner Mongolia People's Hospital. star strain - cheese lactobacillus isolated in 2002 from the Inner Mongolia Xilin Guole prairie natural fermentation of sour horse milk, is China's first strain to complete the genome-wide sequencing of lactic acid bacteria. After scientific research, it has been found that cheesecella Zhang can regulate the intestinal bacteri group, improve immunity, prevent upper respiratory tract infections in the middle-aged and elderly population, regulate the younger intestinal bacteria, etc. As of January 2021, 16 patents have been filed and 172 papers have been published around the case of Bacillus Cheese Zhang. The Bacillus Cheese Zhang gene map published last year: Eur. J. Lipid Sci. Technol. 2012, 114, 244–252