What advantage does calcium antagonist have to fall blood pressure?

Calcium antagonists are a common type of antihypertensive drugs (http:// mainly including nifedipine, nifedipine and amlodipine What are the benefits of these drugs in the treatment of hypertension? Zhao Yiye, chief physician of the cardiovascular department of the hospital of Integrative Chinese and Western medicine, Southern Medical University, introduced the relevant contents What is the mechanism of calcium antagonists? Zhao Yiye, chief physician, introduced that calcium antagonists, also known as calcium channel blockers, have five main functions: 1 Negative inotropic effect: by blocking the flow of calcium ions through calcium channels, reducing the concentration of free calcium ions in the plasma of cells, thereby weakening the myocardial contractility 2 Negative frequency and negative conduction: prolonging the conduction and refractory of atrioventricular node, often used to treat supraventricular tachycardia caused by reentry 3 Anti cardiac hypertrophy effect: calcium antagonists can inhibit calcium influx, reduce intracellular free calcium concentration, significantly reverse cardiac hypertrophy, improve left ventricular filling, and increase coronary artery reserve 4 Dilation of coronary artery: all kinds of calcium antagonists can dilate large and small coronary arteries and improve collateral circulation, among which dihydropyridine is the most significant one 5 Dilate the arteries of brain, kidney, mesentery and limbs: it can be used to treat cerebral and peripheral vasospasm Zhao Yiye, chief physician, explained that there are many mechanisms of action of calcium antagonists On this basis, it can also be subdivided, and the indications of different types of calcium antagonists are different: dihydropyridines mainly dilate arteries Nifedipine (nifedipine), nifedipine sustained-release or controlled release agents, amlodipine and lacidi are commonly used
The advantage of nifedipine is that it can take or swallow quickly, but at present it is only used to temporarily control the elevated blood pressure, because it will increase the mortality rate, so it is not recommended to take it for a long time; the advantage of nifedipine slow release agent is that it can release the drug slowly, reduce the number of times and dosage; while amlodipine has a definite antihypertensive effect, and it will not reflexively accelerate the heart rate, and long-term application will not increase it It can be used in patients with coronary heart disease, arrhythmia, heart failure and hypertension Phenylalkanes: mainly negative inotropic frequency Verapamil and its sustained-release agents can slow down the heart rate, so they are mainly used to treat and prevent supraventricular arrhythmia; verapamil also has the effect of dilating peripheral blood vessels, reducing blood pressure, but weaker Benzothiazines: it can not only dilate arteries, but also have negative effects on the negative frequency of muscle strength Including diltiazem and its slow release agent It is the first choice for variant angina pectoris because it can dilate artery, prevent coronary spasm and reduce myocardial oxygen consumption due to its negative myodynamia and negative frequency In summary, calcium antagonists can also be used in angina pectoris, supraventricular arrhythmia, and lower incidence rate and mortality of subarachnoid hemorrhage besides hypertension Due to the emphasis on personalized medication for cardiovascular and cerebrovascular diseases such as hypertension, patients need to use drugs correctly under the guidance of doctors after going to hospital, and cannot change drugs at will (http://