What drugs lead to an increase in creatinine levels?

Creatinine is a by-product of sarcosine and a part of muscle Doctors can determine renal function by checking creatinine levels If there is too much creatinine, it means there is a problem with kidney function Some drugs are known to cause an increase in creatinine levels Chemotherapy drugs: cisplatin, carboplatin, carmustine, mitomycin, methotrexate and other chemotherapy drugs can cause kidney damage and improve the level of creatinine So patients must have a creatinine test before using the drug to make sure the kidney can take it Antibiotics: amphotericin B, gentamicin, vancomycin and other antibiotics can cause kidney damage and increase the amount of creatinine ACE inhibitors: ACE inhibitors are often used in patients after a heart attack because they enhance cardiovascular function and reduce blood pressure Patients with impaired renal function (such as renal artery stenosis) should not take this drug because it can further damage the kidney and improve creatinine levels NSAIDs: painkillers such as ibuprofen, aspirin and naproxen can cause side effects such as kidney failure It is these side effects that make it one of the drug types that can lead to an increase in creatinine levels Diuretics: diuretics such as furoanilic acid can also cause an increase in creatinine Long term use of diuretics can lead to kidney overwork, which not only increases sodium intake, but also further increases creatinine levels, according to the US health website.