What happens when I inject a clip of the longevity hormone Closo?

What happens when I inject a clip of the longevity hormone Closo? A new study recently found that a single injection of the longevity hormone Closo fragments into young and old mice improved their spatial and working memory, as well as rapidly enhanced connections between neurons in the brain's seahorses, and that these cognitive improvements can last for weeks.
related papers were recently published in the journal Cell-Communication.
addition, short-term treatment of Closo fragments can reverse cognitive and motor impairments in mice with intellectual disabilities.
but researchers say clinical trials are needed to test the safety and effectiveness of the method before it can be used in humans.
" cognitive disorder treatment has become a major biomedical challenge, there is no effective treatment.
our findings suggest that Closo fragment therapy, which enhances brain function, may be a new treatment for neurodegenerative diseases such as Alzheimer's and Parkinson's.
," said Dena Dubal, a neuroscientist at the University of California, San Francisco and senior author of the paper.
high levels of closol hormones, which are naturally produced, regulate multiple signaling paths and cellular processes and are associated with increased life expectancy in worms, mice and humans.
in animal models, Closo decreases with age, chronic stress, cognitive aging, and neurodegenerative diseases.
the study, The Dubal team injected mice with alpha-KL-F, similar to the naturally secreted closo hormone.
, the young mice showed increased spatial learning and memory in a water maze test.
after a single injection of alpha KL-F, they also showed increased working memory in local Y maze tests.
these cognitive boosts lasted at least 2 weeks after the last treatment.
but older mice showed improvements in spatial and working memory after a single injection of alpha KL-F.
the researchers said additional experiments showed that alpha KL-F treatment could reverse the movement and cognitive impairment of mentally handicapped mice after a few days.
scientists increased levels of alpha-synuclein proteins in mice linked to diseases such as Alzheimer's and Parkinson's.
next step, the researchers plan to explore how alpha KL-F transmits signals to the brain to improve nerve recovery and cognitive function.
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