What is nucleic acid? Nucleic acid signal transducing research.

What is nucleic acid, nucleic acid is the storage and transmission of genetic information, is an important material basis for the continuation of life.
As a genetic material, the special nucleic acid secondary structure and various chemical modifications of nucleic acids affect their biological function, and by the mutual transformation of these different structures or modifications, affect and determine the downstream life process, which is the signal transduction associated with nucleic acids.
In the fund committee-funded "signal transduction process research based on chemical small molecule probe" major research program, scientists from the four-strand nucleic acid liant regulation, based on modified nucleic acids and irregular nucleic acid structure, etc. to explore the role of nucleic acids in signal transduction.
Xiaogang, a researcher at the Chun Institute of Applied Chemistry of the Chinese Academy of Sciences, conducted research on the regulation of the li curing of four-strand nucleic acids.
study found that a hand-like supermolegic compound called an "M-pair" and a nucleic acid known as an "advanced G-four-chain djumer" have a strong binding capacity.
the research of Qu Xiaogang's research group shows that "advanced G-four-chain djumer" can be used as a new target of G-four-chain active ligation, and provides a new idea for the design of ligation with telomere G-four-chain as the target.
study, researchers also looked at telomere structure and telomerase activity.
They demonstrate for the first time that single-walled carbon nanotubes (SWNTs) induce telomere DNA to form a special four-stranded structure called "i-motif", which in turn destroys the structure and function of telomeres and effectively inhibits telomerase activity, which is important for understanding the biological function of this particular telomere structure in cells and the biomedical effects of SWNTs in cancer cells.
same time, the Songyangzhou Team at Sun Yat-sen University found that in human cells, a protein called TPP1 recruits more telomerase to telomeres during and late DNA synthesis.
previous studies have shown that an area called OB-fold is the exact region where telomerase binds to TPP1, and that multiple bits of TPP1 are phosphate.
songyangzhou task force researchers learned from structural analysis that phosphate S111 in TPP1 OB fold telomerase mutual domain.
when researchers used mutations to destroy S111, they found that it could lead to reduced telomerase activity and shorter telomeres in the TPP1 complex.
the study provides a research basis for a deeper understanding of telomerase recruitment and telomere extension mechanisms that regulate cell cycles through TPP1 phosphatization.
since nucleic acids are an important source of many major diseases, the identification and regulation of small molecules of nucleic acids can also provide important theoretical basis and technical methods for the diagnosis and treatment of major diseases.
Zhou Xiang's team at Wuhan University found that the different modifications of "CpG Island", an area rich in polybird ostrich cytosine in DNA, had different effects on the transformation of DNA configuration.
This study shows that methylization of 5-methyl cytosine (5mC) and the modification of pyridine promote the conversion of the two-wave helix (B-DNA) of the left-handed pattern into the two-wave helix (Z-DNA) of the left-handed pattern, while the modification of 5-hydroxymide (5hmC) inhibits this transformation.
researchers believe the findings have important presomnical genetic significance.
present, the detection technology of modified nucleic acid is an important part of the study of ostogenesis, and the identification of modified nucleic acids by chemical small molecules is an important direction.
the halogenated ammonium salt derivatives they synthesize can highly selectively identify 5mC in the DNA chain, distinguish between 5mC and 5hmC, and 5-aldehyde-based cytosine, and are expected to incorporate next-generation sequencing methods to provide powerful tools for the study of osclogene and cancer diagnosis.
based on this, they have also developed a genome-wide 5-aldehyde-based cytosine detection technology.
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