What is the development of DNA coding compound library technology?

On October 19, 2018, landmark Chengdu was jointly sponsored by Chengdu pilot drug development Co., Ltd., Pfizer Asia innovation center, MSD R & D (China), Johnson & Johnson Asia Pacific innovation center, GlaxoSmithKline and Shenzhen micro core biotechnology, and hosted by pharmaceutical intelligence network (Chongqing Kangzhou big data Co., Ltd.) "the 8th International peak of DNA coding compound library technology "Forum" and "2018 International Summit Forum on frontier and practice of innovative drug discovery" were held at the same time Adhering to the theme of "innovation, pragmatism and cooperation", more than 1000 people gathered in Chengdu to share the feast The conference invited 68 domestic and foreign heavyweight experts and scholars from government regulatory departments, academia, industry, business and venture capital circles to give keynote speeches, focusing on domestic and foreign biomedical market analysis and policy analysis, studying and judging the new trend of intelligent medical industry, discussing new targets and technologies for new drug research and development, and sharing many domestic and foreign first-line new drug research and development examples It is worth noting that as a global professional summit focusing on the field of del, the 8th International Summit Forum on DNA coding compound library technology has been transferred to China for the first time The past seven sessions have been held in Boston, the United States and Zurich, Switzerland This year, it will be held in turn in the United States, Switzerland and Chengdu, China During the conference, Dr Barry Morgan, the main inventor of DNA coding compound library technology and the lead chief scientist in Chengdu, Dr Nick Terrett, the vice president of science of European Ministry of chemistry in moshadong and the inventor of Viagra Viagra, Dr Kenneth E, the manager of scientific computing research and development platform of GSK Dr Lind, Professor of the Department of chemistry and Applied Biosciences of Swiss Federal Institute of technology and co-founder of philogen, and founder of the International Summit Forum on DNA coding compound library technology, was interviewed by Dr Dario Neri, a reporter from pharmaceutical intelligence network (left) Dr Barry Morgan, Dr Nick Terrett, Dr Kenneth E Lind, Professor Dario Neri (right): what is the development of DNA coding compound library technology? Dr Nick Terrett (vice president of science, European Ministry of chemistry, moshadong, inventor of Viagra Viagra): more than 20 years ago, combinatorial chemistry was put into industrial application Its purpose was to synthesize a large number of diverse compounds in a short time and find drug molecules from them In the 1990s, many technologies were invented in academia and industry to synthesize high-quality compound libraries In many combinatorial chemistry methods, DNA coding compound library technology has been paid attention to and widely used in industry From the DNA coding compound technology, many targeting compounds have been found, optimized to lead compounds, and several compounds have entered the clinical stage This fully proves the influence of DNA coding compound technology Reporter: what kind of cutting-edge information are you sharing at this meeting in Chengdu? Dr Barry Morgan (the main inventor of DNA coding compound library technology and the lead scientist in Chengdu): I think there are two important cutting-edge information: first, we see the compounds screened from the DNA coding compound library enter the clinical research, which will change the life of patients; second, we have learned a lot of new DNA compatible chemical reactions, and colleagues from academia and industry have done a lot of new work here Dr Kenneth E Lind (R & D platform manager of GSK Scientific Computing): I agree with Barry I am impressed by the new chemistry and its application in DNA coding compound library On the other hand, we can understand the new screening methods of DNA coding compound library Reporter: this forum was held in Chengdu for the first time What's the different feeling from the previous participation? Professor Dario Neri (Professor of the Department of chemistry and Applied Biosciences and co-founder of philogen, Swiss Federal Institute of technology, and founder of the International Summit Forum on DNA coding compound library technology): This is the best one The organizing committee has organized this meeting very well, with very good speech topics and very new scientific progress Reporter: what is the biggest challenge in the construction of DNA coding compound library? Dario Neri: quantity and quality of DNA coding compound library Nick Terrett: it will be a challenge for DNA coding compound library to construct DNA coding compound library with diverse structure and drug-like properties, and to find out drug-like molecules through the screening of compound library Kenneth E Lind: it's very important to find high-quality molecules through DNA coding compound library; secondly, we should also consider improving the screening method of DNA coding compound library Reporter: what do you think of the DNA coding Compound Library Technology Summit Forum held in Chengdu? Nick Terrett: This is my second visit to Chengdu I am very impressed by Chengdu Especially the development of biological city shocked me Reporter: when Chengdu joined Zurich and Boston this year, the three cities will hold this summit forum in turn What's your expectation? Dario Neri: Chengdu is an important and equal partner I think this rotating mechanism is very good and should be continued Since the second International Forum on frontier and practice of innovative drug discovery, I have participated in it Today it is the third one The trend is that the number of people and technology of the summit are increasing dramatically Barry Morgan: if we combine short-term and long-term benefits, I think this kind of Academic Summit has far-reaching significance for the industry and Chengdu Thanks to Dr Barry Morgan, Dr Nick Terrett, Dr Kenneth E Lind and Professor Dario Neri for their interviews Statement: this opinion only represents the author, not the position of yaozhi.com, welcome to exchange and supplement in the message area; if you need to reprint, please be sure to indicate the author and source of the article.