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What makes the protein channel open and close |
MSCS channel protein (pink) and its related lipids (dark green, light green, red) are embedded in the nanodisc (gray).
MSCS channel protein (pink) and its related lipids (dark green, light green, red) are embedded in the nanodisc (gray).
However, it is difficult to study these channels in the laboratory, so how they open and close and finally end in a desensitized state through a subconducting state is still poorly understood.
"We can actually see the entire cycle of a series of functional stages of the protein channel.
The researchers said that MscS, a protein embedded in bacterial membranes, opens under the action of mechanical force.
However, when Zhang Yixiao (transliteration), a postdoctoral fellow in the Walz group, discovered that it was impossible to pry open the channel by diluting the membrane in the natural range.
Walz and Zhang Yixiao decided to break through the limits of nanodisc technology and use β-cyclodextrin to remove membrane lipids, a chemical used to remove cholesterol from cell culture.
The results they observed were consistent with computer simulations and found a new functional model of MscS.
The researchers said that many of these proteins play a key role in humans, from hearing and touch to the regulation of blood pressure, and they are very interesting drug targets.
Related paper information: doi.
doi.