What preparations should be done before the wet mixing granulator is used?

The wet mixing granulator is a kind of solid preparation pharmaceutical equipment that has developed rapidly in recent years.
The process combines the two-step process of mixing and granulation, which not only saves time but also meets the requirements of GMP and reduces cross-contamination.
The efficiency is improved, which is a method that is much faster and more economical, and is well received by users
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Among the current solid preparation processes, the wet mixing granulator is the most used granulation equipment and is also more economical
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According to incomplete statistics in the pharmaceutical industry, it has accounted for 70% of all solid preparation granulation equipment
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Working principle: The object material and the adhesive are mixed in a cylindrical container to form a moist soft material, and then cut into uniform wet particles by the side-mounted high-speed breaking pulp
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The atomizer metering spray ensures uniform and stable particle composition, high production efficiency, good particle fluidity, high compression and filling
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The granules produced by the wet mixing granulator are harder, stronger and rounder than those produced by the top jet fluidized bed
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Generally, the granules are discharged into the granulator to destroy the oversized agglomerates, and then sent to the fluidized bed for drying
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The wet mixing granulator adopts a horizontal cylinder structure, fully seals the drive shaft, and can be switched to water when cleaning
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Fluidized granulation, the granulation is approximately spherical, and the fluidity is good
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Compared with the traditional technology, the adhesive is reduced by 25%, and the boring time is shortened
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Dry mixing for 2 minutes without batch, granulation for 1-4 minutes, the effect is 4-5 times better than traditional technology
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Finished in the same closed container, dry mixing - wet mixing - granulation, technical reduction, in line with GMP standards
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The entire operation has strict safety protection measures
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　　At present, the product uses a touch screen control interface, which is intuitive and convenient to operate, and the technical parameters can store Chinese patent medicine, composition tablet, capsule granule production, instant drink granule production and chemical granule production
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 　　Preparations before using the wet mixing granulator: 1.
Check whether the clearance site is qualified, the flow of people and logistics channels should be unobstructed, and the debris on site should be cleaned up; 2.
Check whether the tools required for this position are complete; 3.
Check Name, specification, qualification certificate of raw and auxiliary materials; 4.
Open the three-way ball valve of compressed air and rotate it to the ventilation position, adjust the valve opening, so that the air pressure is 0.
5MPa; 5.
Turn on the main power supply and observe the electrical operation screen, when the signal indicates When the light is on, the material pot cover can be opened; 6.
Check the air intake air flow in the center of the stirring blade chopper, and adjust the flow meter on the air flow operation panel according to the actual situation
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Rotate the stirring paddle and the chopping knife by hand.
There should be no abnormality in the rotation, and then close the material pot cover and the discharge cover; 7.
Open the observation cover, jog the two motors, and observe the rotation direction of the stirring paddle and the chopping knife.
for counterclockwise rotation
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Otherwise, notify the electrician to reconnect the power cord; 8.
Operate the discharge and stop buttons to check that the advance and retreat of the discharge piston should be flexible and the movement speed should be moderate
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Otherwise, the joint or one-way throttle valve under the cylinder can be adjusted
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Then close the discharge piston; 9.
Open the main water valve first, then turn the three-way ball valve to the water-passing position, and pass the water to the upper edge of the shredding bearing
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Open the material pot cover, observe the water level in the center of the stirring paddle and the chopper, and check that there should be no leakage at each seal; 10.
Turn the three-way ball valve to the ventilation position
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Close the material pot lid
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Turn on the stirring and chopping motors, and check the no-load operation and sealing through the observation port; 11.
Control the discharge piston, drain the water, and dry the material pot; 12.
Check the running part, the opening degree should run smoothly
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The procedures of the safety interlocking device should be correct; 13.
The material pot cover is provided with interlocking and delay devices
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Only when the power is turned on and the motor stops, and the door signal light is on, it is possible to open the material pot cover
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If the cover is not opened within the delay time of opening the cover, the cover will be locked again and the door signal light will be turned off
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At this time, do not force open the material pot cover, press the emergency stop button and resume, the door signal light is on, then the material pot cover can be opened
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