What proteins are associated with the Zika virus epidemic?

In the past year, the Zika virus has become the focus of virological research.
as scientists learn more about the virus, which can cause a range of health problems, such as glycephaly and Greene-Barre syndrome, how does the virus damage cells? Which proteins are associated with it? It is not yet clear.
researchers at the University of Maryland School of Medicine said in a paper published In the Proceedings of the National Academy of Sciences on Sunday, they identified for the first time seven key Zika virus proteins that may be responsible for the Zika virus's ravages.
the study, the researchers used cleavage yeast.
originally used to make beer, in recent decades has been widely used in cell biology research, is the most typical biological model of cell division to date.
, Zhao Yuqi, a professor of pathology at the University of Maryland School of Medicine who led the study, used a cleavage yeast model to study HIV and barley yellow dwarf virus, and had a very mature approach to research.
, he and colleagues used induced startup factors to parse 14 proteins or peptides from the Zika virus.
, they exposed the cleavage yeast cells to each of the 14 proteins to observe the cell's response.
found that seven of these proteins, or peptides, have different cell pathological effects that somehow damage yeast cells.
may limit cell proliferation, or lead to cell hypertrophomation, or even trigger cell oxidative stress reactions leading to cell death.
Zhao Yuqi said the mechanism of zika virus disease is mysterious, and the new findings give scientists a deeper understanding of how the virus affects cells, which is important for the global fight against the Zika virus and future research.
next step, the researchers will focus on the effects of these seven proteins on the human body.
of these proteins, some may be more damaging, others may need to work together to cause disease, and these problems need to be studied more deeply to understand.
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