What role can antiviral small and medium-sized molecule drugs play? Expert answers

The joint prevention and control mechanism of the State Council held a press conference
on the 9th on the relevant situation of the tenth edition of the diagnosis and treatment plan.
Wang Guiqiang, director of the Department of Infectious Diseases of Peking University First Hospital, pointed out at the meeting that the use of antiviral oral small molecule drugs can help patients reduce the risk of severe disease and hospitalization, and even reduce the risk of death, but the indications should be strictly mastered and used
under the guidance of doctors.

 

At the meeting, a reporter asked: In the treatment of antiviruses, what role can small molecule drugs mainly play?

 

Wang Guiqiang introduced that since the outbreak of the new crown virus infection, he has been exploring treatment methods and has accumulated a lot of experience
.
However, so far, there is no specific drug to treat new coronavirus infection, and comprehensive treatment is still emphasized, including symptomatic supportive treatment, early antiviral therapy, early oxygen therapy, immunotherapy, anticoagulation therapy, etc.
, and for important organ failure, such as respiratory failure, there is also respiratory support treatment and organ function support
.
Antiviral therapy is an important part of comprehensive treatment, the tenth edition of the diagnosis and treatment plan antiviral therapy includes oral small molecule antiviral drugs, three drug recommendations, in addition, convalescent plasma and new crown immunoglobulin, monoclonal antibodies are antiviral treatment drugs
.

 

He mentioned that small molecule oral antivirals clear or inhibit the virus by directly inhibiting viral replication, reducing clinical symptoms, shortening the course of the disease, reducing the risk of severe disease, and ultimately reducing the risk of
hospitalization and death.
It is characterized by oral administration, which is more convenient, and can be used in hospitals, as well as in communities, clinics, and outpatient clinics
.
However, emphasizing small molecule oral antiviral drugs, one is early use, the sooner the better, generally within 5 days of use is the best, 5 days outside the use of the effect is greatly reduced
.
Another is to use it for people at high risk of severe disease, that is, the elderly, those with underlying diseases, those who have not been vaccinated, etc.
, these high-risk groups of severe disease are prioritized for use, which can reduce the risk of
severe disease.
The general population is not of great value after infection
.
Because the drug has interactions and adverse reactions, it is emphasized to use
under the guidance of a doctor.
In summary, the use of antiviral oral small molecule drugs can help patients reduce the risk of severe disease and hospitalization, and even reduce the risk of death, but the indications should be strictly mastered and used
under the guidance of doctors.