Whether the frustration quotient is high or not, dopamine has the final say; The ability to resist pressure is not strong, dopamine has the final say: the VTA-NAc loop is the key!!

Chinese summary

Chronic stress may have lasting adverse consequences for some people, but others can resist
the same stress.
After the end of stress stress, stress-susceptible and stress-resistant people show differences
in intrinsic properties of dopamine (DA) neurons in the midbrain-limbic system.
However, the causal relationship between dopamine and behavioral and individual resistance differences under stress is unclear
.
In this study, the researchers recorded the behavior of mice during social defeat and the activity of DA neurons projected to the nucleus accumbens (NAc), which signals reward, and the caudal striatum (TS), which signals threats.

Quantification of supervised and unsupervised behavior showed that stress-resistant and stress-susceptible mice used different behavioral strategies during stress, with different activity patterns
at the end of DA neurons in NAc rather than TS.
At the level of neural mechanisms, stress-resistant mice had stronger DA neuronal activity near the aggressor, including at the beginning of fighting back
.
In contrast, stress-susceptible mice had stronger DA neuronal activity
at the onset of attack failure and flight.
With a real-time behavioral classification method, the researchers also used optogenetic means to specifically activate DA neurons
projected to NAcs using optogenetic means when mice were thwarted (random-open-loop stimulation) or performing specific behaviors.
Both loop-opening counterattack stimuli or timed activation enhance the mouse's resistance to stress and reorganize behavior during defeat to form resistance-related patterns
.
Together, their findings revealed a link
between DA neuronal activity, resistance, and stress resistance-related behavior.