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Researchers at the University of Utah, in collaboration with their Australian counterparts, have discovered the molecular structure of insulin in the venom produced by snails, a natural insulin that regulates blood sugar levels in just five minutes, compared with the fastest artificial insulin in 15 minutes, the university's official website said in a statement.
insulin is a hormone secreted by the pancreas associated with glucose intake, which contains areas A and B.
is generally due to impaired pancreatic function can not normally secrete insulin, the most effective treatment is currently artificial insulin injection.
But the B-zone portion of insulin causes insulin molecules to converg into a polymer of six molecules, and the insulin injected needs to degrade the aggregated insulin into a single molecule before it can work on the patient, a process that often takes an hour, even if the fastest insulin on the market takes 15 to 30 minutes to become medicinal.
scientists tried to remove the B-zone part, but the consequence was that insulin was completely drug-free.
paper, published in the journal Nature Structural and Molecular Biology, biologist Helena Safawe found that insulin in snail venom does not contain a B-zone portion and therefore does not cause the accumulation of insulin molecules.
tests showed that snail insulin still has a blood sugar-lowering function and can work quickly in less than five minutes, although not as good as human insulin.
when snails prey on fish, they often secrete some venom into the water, allowing nearby fish blood sugar to peak and then drop rapidly to cause the fish to faint, and the snail can have a full meal.
in long-term fishing operations, snail insulin has evolved and has a rapid response function.
The next step for
researchers will be to constantly modify the artificial insulin structure based on the structure of the snail insulin, allowing the latter to maintain a sugar-lowering effect after losing the B-zone portion;
In addition, researchers are working on artificial pancreatic devices that simulate the bodies' pancreas automatically transmitting insulin doses to the body based on blood sugar levels, a device that could be developed next year and could be used in artificial pancreas devices in the future.
source: China Biotechnology Network.