WHO's latest recommendation: HPV vaccine is effective with only one shot, and this evidence is very important!

The WHO Strategic Expert Advisory Group on Immunization (SAGE) , convened from 4 to 7 April, assessed emerging evidence over the past few years that single-dose schedules have comparable efficacy to two- or three-dose schedules

The WHO Strategic Expert Advisory Group on Immunization (SAGE) , convened from 4 to 7 April, assessed emerging evidence over the past few years that single-dose schedules have comparable efficacy to two- or three-dose schedules

The SAGE review concluded that the single-dose human papillomavirus (HPV) vaccine provided solid protection against HPV, the virus that causes cervical cancer, comparable to the two-dose regimen

Cervical cancer is the fourth most common cancer in women worldwide

In order to prove the protective efficacy of a single dose of HPV quadrivalent vaccine in preventing cervical cancer, scholars from India started a trial in 2009, including more than 17,000 girls aged 10-18 years old vaccinated with 1, 2 or 3 doses doses of quadrivalent HPV vaccine and long-term follow-up

In order to prove the protective efficacy of a single dose of HPV quadrivalent vaccine in preventing cervical cancer, scholars from India started a trial in 2009, including more than 17,000 girls aged 10-18 years old vaccinated with 1, 2 or 3 doses doses of quadrivalent HPV vaccine and long-term follow-up

All subjects were divided into four cohorts: 2-dose vaccine cohort (4980 cases); 3-dose vaccine cohort (4348 cases); did not complete the scheduled protocol and actually received 2-dose vaccine cohort (3452 cases); did not complete the scheduled protocol, Actual 1-dose vaccine cohort (4949 cases)

In further analysis, the single-dose HPV quadrivalent vaccine was 35.

Incidence of HPV 16/18 infection in subjects vaccinated with different doses of vaccine

Incidence of HPV 16/18 infection in subjects vaccinated with different doses of vaccine

It can be seen that the protective efficacy of a single dose of HPV quadrivalent vaccine against persistent infection was not significantly different from that of 2 or 3 doses of HPV quadrivalent vaccine

It can be seen that the protective efficacy of a single dose of HPV quadrivalent vaccine against persistent infection was not significantly different from that of 2 or 3 doses of HPV quadrivalent vaccine

In conclusion, the WHO SAGE panel, after comprehensively evaluating the scientific evidence obtained over the past few years, concluded that a single dose of HPV vaccine can provide reliable protection comparable to a 2- or 3-dose regimen

references:

references:

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Vaccine efficacy against persistent human papillomavirus (HPV) 16/18 infection at 10 years after one, two, and three doses of quadrivalent HPV vaccine in girls in India: a multicentre, prospective, cohortstudy.
The Lancet Oncology 22.
11 (2021): 1518 -1529.


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