Why does the cold make the toothache

The cold sensation on teeth is mediated by odontoblasts and transmitted to the brain through nerves, so that pain can be felt.

Recently, researchers reported in "Science Advances" that they have discovered a new function of odontoblasts.

"We found that odontoblasts support the shape of the tooth and are also responsible for sensing the cold.

There are many reasons for tooth pain when exposed to the cold.

In previous studies, the research team discovered that a protein encoded by the TRCP5 gene is expressed in nerves in many parts of the body.

Lennerz said: "We now have conclusive evidence that the temperature sensor TRCP5 spreads cold through odontoblasts and triggers nerves to cause pain and cold allergies.

Specifically, in the cold, the TRCP5 protein opens the tunnel into the dentin cell membrane, allowing other molecules, such as calcium, to enter and interact with the cell.

Lennerz said: “Most cells and tissues slow down their metabolism in a cold environment, which is why donated organs are frozen.

The research team also identified a drug target that can reduce the sensitivity of teeth to cold.

Related paper information: doi.