Why tumors are more "favored" by young women.

Mucus ovarian tumors (MOTs) are morphologically and epidemiologically similar to pancreatic mucus cystic tumors (MCNs) and have similar methological properties that occur disproportionately in young women.
in the latest study, scientists from the University of Neva (UNIGE) and others found that both tumors originate from embryonic reproductive cells that migrate to the reproductive organs without differentiation.
during the migration process, some may mistakenly stop in other organs, which in turn puts you at risk of developing tumours after 30 years.
scientists believe that better classification of these mucus tumors could pave the way for more appropriate and personalized cancer source management.
women aged 1 to 30 to 40 are more likely to affect ovarian and pancreatic mucus tumors in young women between the ages of 30 and 40, accounting for about 3% of ovarian and pancreatic cancers, and usually have the tumour completely removed through timely surgery.
however, 15% of cases ruptured the cyst before surgery, causing cancer cells to spread to the peritoneal cell, causing a metastasis that is highly resistant to chemotherapy.
in this case, the patient's survival prognosis is not more than one year.
initially based on clinical observation, said Dr. Intidhar Labidi-Galy, a research author and researcher at UNIGE School of Medicine, who wrote in a detailed article detailing the genetic characteristics of pancreatic mucus tumors, and was surprised to find that although there was no direct relationship between the two organs, the two locations had the same genetic changes. "We found the same genetic mutations, and the same type of victims - young women who smoke regularly," said lead author Dr. Kevin Elias, pointing to the close link between the two tumors.
What is the link between
2, a common origin ovary and pancreas? "These organs are only really close to the embryo situated.
," Dr. Labidi-Galy said.
in the early stages of pregnancy, the embryo has primitive reproductive cells (early cells that produce male and female reproductive cells); The intestinal membranes, which eventually reach the developing reproductive palate and form the testicles or ovaries together with the mid-embryo cells of the reproductive crucibles, pass through the future pancreas and reach the contours of the reproductive glands around 7 weeks of pregnancy (the arrive at the epigenetics).
most likely, some of these reproductive cells stopped moving en route.
using a public database, the study authors developed a transcription map that identifies the original reproductive cells at 6, 7, 11, 16 and 17 weeks of pregnancy, as well as the level of gene expression of tumors and healthy ovary and pancreas cells.
, the researchers then looked at healthy tissue, mucus tumors and other types of tumors in both organs, and compared pancreatic and ovarian data, and they clearly gave the results: in both cases, the transcription of mucus tumors was far away from the assumed original tissue (ovary or pancreas) but very close to the original reproductive cells.
this proves that these tumors are closer to the original reproductive cells than to the organs in which they grow.
3, accidental cessation of results during migration showed that accidental cell migration cessation during these women's embryonic periods may be expressed as cancer decades later, depending on some other risk factors (such as smoking) and the "settled" location of these primary reproductive cells in the body.
fact, although scientists have examined the pancreas and ovaries, similar situations have been found in reproductive cell migration, especially in the liver or peritoneal membranes.
"Our results will not change the surgical management of these patients, but may lead us to rethink chemotherapy."
these rare tumors are a bit like cancer orphan diseases, with no standard treatment.
by linking them to other cancers, we want to find effective treatments.
What is the best treatment for every mutation? Understanding every detail of these 'enemies' makes it easier for us to fight it," concludes Labidi-Galy.
Source: Biological Exploration.