WIREs │ Yu Meng, Wang Yongxia team of Southern Medical University: A nano-drug delivery strategy to regulate the tumor microenvironment is used to overcome tumor multidrug resistance

The occurrence of drug resistance has largely limited the effectiveness

Associate Professor Yu Meng of Southern Medical University and Yongxia Wang, Director of the Department of Mammary Science, Dongguan Hospital Affiliated to Southern Medical University, reviewed the relationship between the main characteristics of tumor microenvironment and drug resistance, and summarized the current application of different microenvironment regulatory strategies in the treatment of drug-resistant tumors (Figure 1).

In this review, the authors discuss the mechanisms by which key features of TME, such as hypoxia, microacidity, immunity, microbiology, and metabolism, lead to tumor resistance, and summarize a series of studies

In recent years, the design of nano-drug delivery systems is no longer limited to passively responding to TME, but gradually deepens into active micro-environment regulation

Original link:

https://wires.

About the author

Yu Meng, Ph.
D.
in Pharmacy, Associate Professor of Southern Medical University, Master Supervisor
.

In recent years, a series of work
has been carried out around the application of intelligent response drug delivery system in the regulation and treatment of the microenvironment of lesions.

He has published more than 40 SCI papers in international journals such as ACS Nano, Advanced Science, Small Methods, Nano Letters, Bioactive Materials, Biomaterials, Journal of Controlled Release, Acta Pharmaceutica Sinica B, etc.
Among them, 15 IF>10, 2 co-edited papers, applied for and authorized 3 domestic patents, papers have been cited more than 1400 times by domestic and foreign counterparts, and the H factor is 24
.

He presided over the National Natural Science Foundation of China Youth Project, Guangdong Provincial Natural Science Foundation Project, Southern Medical University High-level Talent Cultivation Project, etc.
; Serves as a youth editorial board member for SCI magazines Asian J Pharm Sci and Chinese Chem Lett; Standing Committee Member
of Molecular Imaging Branch of Guangdong Precision Medicine Applied Society.

Wang Yongxia, Director and Chief Physician of the Department of Mammary Organs, Red Chamber Branch of Dongguan Hospital Affiliated to Southern Medical University; Adjunct Professor, Southern Medical University; Leader of the professional medical discipline of breast tumors in Dongguan City; Visiting Scholar
, Washington University, St.
Louis, USA.

He is good at the early diagnosis of breast cancer and the comprehensive treatment of breast cancer with surgery, and has rich
experience in clinical practice and diagnosis and treatment of difficult and critical cases.

Committed to clinical and basic research related to breast tumor, presided over and participated in Dongguan Shefa Science and Technology Key Project and Guangdong Provincial Scientific Research Fund Project, won the second prize of Dongguan Science and Technology Progress Award, and published more than 20 academic papers in core journals in Chinese
.

He is a member of the Breast Disease Committee of the Chinese Medical Education Association, the vice chairman of the Breast Minimally Invasive Plastic Surgery and Reconstruction Committee of the Guangdong Provincial Primary Medicine Association, the member of the Breast Disease Branch of the Guangdong Medical Association, the member of the Breast Specialist Branch of the Guangdong Medical Doctor Association, the vice chairman of the Breast Disease Branch of the Dongguan Medical Doctor Association, the vice chairman of the Breast Cancer Committee of the Dongguan Anti-Cancer Association, and
the editorial board of the International Medical Health Herald.

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