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    Home > Active Ingredient News > Antitumor Therapy > With a total value of US$189 million, Cinda Biologics has obtained the exclusive license of ROS1/NTRK inhibitor from Baoyuan Pharmaceutical in Greater China

    With a total value of US$189 million, Cinda Biologics has obtained the exclusive license of ROS1/NTRK inhibitor from Baoyuan Pharmaceutical in Greater China

    • Last Update: 2021-06-11
    • Source: Internet
    • Author: User
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    On June 1, 2021, Cinda Biotech and Baoyuan Pharmaceutical jointly announced that the two parties have reached an agreement under which Cinda Bio and Baoyuan Pharmaceutical will jointly develop and commercialize Baoyuan Pharmaceutical's main drug candidate Taletrectinib in Greater China.

    According to the terms of the agreement, Cinda Bio will obtain the right to jointly develop and commercialize Ttaletrectinib in the Greater China Region with Baoyuan Pharmaceutical as an exclusive partner.

    Baoyuan Pharmaceutical will continue to be responsible for the clinical development and registration of Taletrectinib in mainland China, as well as clinical production and commercial production in Greater China.

    Cinda Biotech has the right to jointly develop Taletrectinib and be responsible for registration and approval in Hong Kong, Macau and Taiwan.

    According to the agreement, Baoyuan Pharmaceutical will receive a total of up to 189 million U.
    S.
    dollars in advance payment and development cost funding and potential milestone payments, as well as royalties based on Taletrectinib's annual net sales in Greater China.

    Taletrectinib is a next-generation tyrosine kinase inhibitor targeting ROS1 and NTRK.
    It is currently undergoing three phase II clinical trials, including one in China for initial treatment of first-line TKI and ROS1 positive for second-line TKI treatment.
    Phase II clinical trial for non-small cell lung cancer, a phase II clinical trial for NTRK-positive solid tumors in China, and a second-line clinical trial for first-line and second-line ROS1-positive non-small cell lung cancer in the world.
    Phase clinical trials.

    As of January 15, 2021, an ongoing Phase II clinical trial of Taletrectinib (TRUST) showed that among 11 patients with advanced ROS1-positive non-small cell lung cancer who were not treated with ROS1 TKI, the ORR judged by the investigator was 100% ; At the same time Taletrectinib shows good safety.

    These data indicate that Taletrectinib may become best-in-class.

    More data on Taletrectinib's first-line (ROS1 TKI initial treatment) and second-line (ROS1 TKI treatment) treatment of ROS1-positive non-small cell lung cancer will be published at the 2021 ASCO meeting.

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