With this new technology, gastric cancer detection bid farewell to gastroscopy and barium meal

Gastroscope and barium meal are currently the two most commonly used methods for detecting gastric cancer

Gastric cancer is not easily detected at an early stage, leading to a higher mortality rate

"DNA methylation to detect cancer" may become a new solution

The specificity of gastric cancer methylation markers is close to 100%

As one of the corresponding authors of the article, Associate Researcher Wen Lu introduced to a reporter from Science and Technology Daily that in 2015, based on the distribution characteristics of CpG short tandem sequences in the human genome, researchers developed a new technology MCTA-Seq that uses a single targeted primer to capture Nearly 9,000 CpG short tandem sequence methylation information, and use this technology for non-invasive detection of hepatocellular carcinoma; in 2019, researchers applied the technology to early non-invasive detection of colorectal cancer; in a paper published in 2021 Researchers have further applied this technology to early non-invasive detection of gastric cancer and non-invasive differential detection of three types of gastrointestinal cancers

In this study, researchers identified a set of methylation markers that distinguish gastric cancer from normal gastric mucosa, and another set of methylation markers that distinguish gastric cancer, colorectal cancer, and liver cancer

"However, starting from the current sample size and experimental results, this technology is still about 5 years away from clinical application

The biggest advantage of DNA methylation detection methods is non-invasive

Gastroscope and barium meal are currently the two most commonly used methods for detecting gastric cancer

"The prospect of MCTA-Seq for non-invasive tumor early screening is very broad