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Figure 1 Schematic diagram released by the 2021 Nobel Committee on Physiology or Medicine summarizing the discovery of PIEZO (top half), the physiopathological functions it mediates such as touch and proprioceptive perception (bottom half right), as well as structural models and mechanical forces Perception Hypothesis Conjecture (bottom half left)
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So how does the PIEZO protein convert physical and mechanical stimuli into bioelectrical signals? Xiao Bailong and his team have been devoted to answering this core scientific question for nearly 10 years
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During his postdoctoral research in Patapoutian's group in 2012, he first confirmed that PIEZO protein is the first type of mechanically-gated cation channel identified in mammals (Nature 2012).
A series of important research progress has been made in research, which has helped to promote the discovery and research of PIEZO to become the research results of the 2021 Nobel Prize in Physiology or Medicine (Figure 2)
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During his postdoctoral research in Patapoutian's group in 2012, he first confirmed that PIEZO protein is the first type of mechanically-gated cation channel identified in mammals (Nature 2012).
A series of important research progress has been made in research, which has helped to promote the discovery and research of PIEZO to become the research results of the 2021 Nobel Prize in Physiology or Medicine (Figure 2)
.
Figure 2.
Summary of research progress on the molecular mechanism of mechanosensing of PIEZO
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Summary of research progress on the molecular mechanism of mechanosensing of PIEZO
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Fig.
3 Three-dimensional structures of the trimeric three-bladed propeller (left part, top view) and nanobowl (right part, top view) of the PIEZO channel
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3 Three-dimensional structures of the trimeric three-bladed propeller (left part, top view) and nanobowl (right part, top view) of the PIEZO channel
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Figure 4.
3D structure analysis of PIEZO1-liposome cryo-EM
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3D structure analysis of PIEZO1-liposome cryo-EM
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Fig.
5 Bent (left) and flattened (right) 3D structures of PIEZO1
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5 Bent (left) and flattened (right) 3D structures of PIEZO1
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Fig.
6 Deformation parameter measurement and mechanical sensitivity calculation of PIEZO1-liposome from curved to flat
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6 Deformation parameter measurement and mechanical sensitivity calculation of PIEZO1-liposome from curved to flat
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2
2
Figure 7 Nanolever delivery mechanism of PIEZO1
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Figure 8 The cap-transmembrane hydrophobic gate pore mechanism of PIEZO1
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2 2
Figure 9.
The model diagram of the force deformation and gating mechanism of PIEZO1
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The model diagram of the force deformation and gating mechanism of PIEZO1
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