Yang Xi: Focus on bio-3D printing "black technology" for all mankind "printing" health

Introduction: Bio3D printing This "black technology" has developed rapidly in recent years, showing great application value in the field of basic research, clinical medicine and drug development in life sciences!----, the "black technology" of bio-3D printing has developed rapidly in recent years and has shown great application value in the fields of basic research, clinical medicine and drug development in life scienceshas a company in BioBAY Suzhou that specializes in the development of 3D biomedical printing platforms and clinical applications, Knopp Regenerative Medicinerecently, the author had the honor to interview DrYang Xi, Chief Operating Officer of Knopp Regenerative Medicine, to gain an in-depth understanding of the company's black technology01 days time land-based human and biological 3D printing is one of the branches of 3D printing, can be driven by digital 3D model, according to the additive manufacturing principle to locate the assembly of biological materials or cell units, layer by layer to form tissues or organs, not only can ensure the accuracy of the location and distribution of different materials, and after printing cells can be self-assembled or after in vitro maturation to form tissue, is the most popular technology in the manufacture of artificial organs, such as artificial skin, cartilage and even some tissues in the development of the development of the development of the d.CThe founding team of Nopp Regenerative Medicine has an authoritative professional in the field of international 3D printing and extensive operational experience of the top 500 enterprises, and has worked deeply in the field of regenerative medicine for many years, firmly believes in the future of this technologycoincides with the "13th Five-Year Plan" national strategic emerging industry development plan, "Made in China 2025" and a series of tendentious policies, as well as research results in the field of regenerative medicine everywhere, "everyone agreed on the idea of returning home to start a business, together with the 'time and earth lying people'."," DrYang Xi said, recalling his entrepreneurial journey2016, Suzhou Nopp Regenerative Medicine Co., Ltdwas established in Suzhou BioBAYNopp Regenerative Medicine is based on an 3D biomedical printing platform based on Organ Printing United System (OPUS) technology to develop breakthrough artificial tissue alternatives and therapies, while providing new technical solutions for biomedical fields such as clinical research, scientific research, and drug developmentDrYang introduced that, since this is currently the most leading clinical bio-3D printing system, unlike other bio-3D printing companies, Knop's focus is through "independent innovation" and "medical cooperation" two-tube model, so that biological 3D printing cut into the clinical, to meet clinical needs-oriented business developmentAccording to DrYang Xi, The OPUS-based bio3D printing independently developed by KNOM has three technical advantages: (1) OPUS PRO, an integrated multi-nozzle printer with up to 7 print nozzles, breaks through the limits of the printing size of existing 3D printers, and enables all bioprinting materials (including cells, natural macromolecules, inorganic materials, synthetic polymermaterials, etc.) to print simultaneously(2) a clinically practical printing process that prints fine three-dimensional structures with dimension tubes, creates a microenvironment similar to extracellular methtos, and prints tissues of similar strength to the human body(3) Knop Regenerative sedentary formula for bio-inks that are easy to print and have a cell-friendly properties that make the cell activity more than 90% higher after printingcurrently, Knopp Regenerative Medicine has two product development pipelines and three in-depth products, involving artificial skin, bone, cartilage tissue, and has partially completed prototyping and animal validationcompany's independent research and development of OPUS PRO system to fill the gap in China's clinical applicability system, can print clinically practical including bone, cartilage, skin, muscles and other human tissuesWhy shoulddevelop this type of product? DrYang Xi explained to us in detail, as an example: Because of clinical needs, such as diabetics or skin ulcer patients due to various lesions, their skin is not able to fully heal, and patients are at risk of amputation if they continue to deterioratethis time, active tissue substitutes that can bionic the human body are needed to help patients healand in this regard, foreign countries have been ahead of the domestic need for internal innovation to meet clinical and people's livelihood needsin addition, like our country has a large number of nasal ear defects, the need for joint repair patients, of which less than 10/1 has been treated, the current method has a variety of defects, the development of implantable, renewable cartilage has become the expectations of the entire medical communitythe Ministry of Science and Technology has also taken the lead in investing heavily in this area for basic researchNup is developing bio-3D-printed artificial skin and cartilage products that address these clinical needs, avoiding pain and saving medical resourcesthere is a huge gap between patients with defective human tissue in the country and the corresponding products that can really be provided, the emergence of bio-3D printing is expected to achieve "manufacturing in order" of physical complex organsthese have driven the Knope team to work deeply in the field of bio-3D printingestablished so far, Nopp is like an open "academic bully", received a number of "excellent report card" - access to Jiangsu Province science and technology support special funds, Gusu innovation and entrepreneurial leaders special fund support, while building a service to the clinical GMP level of the laboratory, and has been with many well-known domestic research and development institutions and clinical hospitals began to cooperate, and won The Kaiming Venture capital and Tao Investment and other well-known venture capital institutions of favor and investment02 bend overtaking, occupying the commanding heights In fact, as Dr Yang Xi said, the world, especially developed countries have taken 3D printing as a new growth point for future development to cultivate, and strive to seize the future of science and technology and industry commanding heights December 5, 2017, the FDA issued guidance on the manufacture of 3D-printed medical devices, providing recommendations to medical device manufacturers on 3D printing technology, and noting what manufacturers need to include when submitting 3D printed medical device approvals, including thinking about various 3D printing methods, device design, functionality, durability testing, and quality system requirements this is another step to promote the further development of 3D-printed medical devices following the FDA's Release of draft 3D printing guidelines for medical manufacturers in May 2017 at the same time, it also reflects the FDA's attention and practice of 3D printing, an important national strategy 2016, in the "13th Five-Year Plan" and "13th Five-Year Plan" issued by the State Council of China, respectively, mentioned "the development of major intelligent equipment, optoelectronics manufacturing equipment, intelligent robots, additive manufacturing, laser manufacturing and other key equipment and processes to promote the intelligent development of manufacturing industry." focus on the development of mobile internet, quantum information, artificial intelligence and other technologies, promote the development of additive manufacturing, intelligent robots, driverless cars and other technologies" and "additive manufacturing (3D printing), robotics and intelligent manufacturing, supermaterials and nanomaterials and other fields of technology continue to make major breakthroughs, promote the traditional industrial system differentiation and transformation, will reshape the international division of labor in the manufacturing industry pattern; vigorously promote the application of additive manufacturing technology in aerospace, medical devices, transportation equipment, cultural creativity, personalized manufacturing and other fields, accelerate the development of additive manufacturing services, and accelerate the innovation and industrialization of tissue organ repair and alternative materials and implanted medical device products by using new technologies such as additive manufacturing "a new round of scientific and technological revolution and industrial reform is brewing and emerging, and new technological breakthroughs are accelerating industrial change, which will have a great impact on the structure of the world economy and the pattern of industrial competition countries around the world attach great importance to the development of 3D printing (additive manufacturing) as an important part of realizing intelligent manufacturing, promoting changes in production methods, and seizing the competitive commanding heights of advanced manufacturing China is in a critical period of structural adjustment and kinetic energy conversion, speeding up the innovation and development of 3D printing industry will strongly promote the supply-side reform of manufacturing industry and inject new kinetic energy into China's economic development For Knopp, all we have to do is do everything we can ," Dr Yang Xi said 03 is open, but there is no shortcut at present, bio3D printing in some areas of application is obvious for example, you can build more personalized micro-simulated human tissue, overcome the difficulties of tissue damage and organ failure, can replace animal models, improve the success rate of drug screening, can be personalized in the field of plastic surgery, help to create more aesthetically appropriate human tissue despite the huge advantages of regenerative medicine, bio-3D printing technology is far from large-scale industrial applications Dr YangXi calmly thinking, the current domestic biological 3D printing is still in the early stage of industrialization, the need for each practitioner to consolidate the foundation, practice internal skills, medicine must not be half sloppy, insist on doing valuable things in order to finally usher in a breakthrough at the same time, this expected industry also needs the government to introduce a series of long-term and stable support policies in terms of financial support, taxation, market guidance, etc., to speed up the establishment of the relevant access licensing system, shorten the approval process as the industry's "pathfinder", Knop is also actively promoting the development of the entire industry, including communication with relevant government departments and trade associations, such as exchanges and cooperation, in the hope that bio3D printing can really bring about changes in the medical industry "The road is open, but there are no shortcuts, " said Dr Yang Xi, the whole industry is not yet fully competitive, enterprises should work together to promote the development of the industry, we need from the top down and bottom-up efforts "