Yi Chengqi and collaborators in the School of Life Sciences report a new mechanism by which tRNA-m1A modification regulates the function of CD4+ T cells

On September 22, 2022, the team of Li Huabing, a researcher at Shanghai Jiao Tong University School of Medicine, Professor Yi Chengqi at the School of Life Sciences of Peking University, Professor Wu Yuzhang of the Army Military Medical University, and Professor Richard A.

Screenshot of the paper

T cells play a central role

tRNAs play an important role

The study first observed that protein translation-related pathways are regulated during T cell activation, and different tRNAs also show dynamic expression patterns of upregulation at differenttime points, and the tRNA-m1A58 modifier enzyme TRMT6/TRMT61A is also upregulated

The authors then explore the specificity

This study is the first to link tRNA modifications to functional changes in T cells, and systematically explores the specific mechanisms that control translation during primary T cell amplification, showing that the use of tRNA and its modifications can bring significant changes

TRMT61A-mediated tRNA-m1A58 modification is a "translation checkpoint" for CD4⁺ T cell activation and proliferation regulation

Dr.

References:

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2．Liu, F.

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