Zhang Peace Team: Probiotics enhance the nerve stimulation activity of the intestinal bacteria to relieve stress and anxiety

(1) Subjects were subjected to oral plant Lactobacillus P-8 (n-43) or placebo (n-36) for 12 weeks; (2) after intervention, the diversity of fecal flora decreased in the placebo group, while there was no significant change in the probiotic group, and the Aitchison distance of the placebo group fecal flora was significantly higher than that of the probiotic group;(3) There was a significant increase in youthful Bifidobacteria, long Bifidobacteria and tender Clostridium difficile in the faeces of the probiotic group, while there was a significant decrease in fecal Ross bacteria, and (4) probiotics were associated with the synthesis/consumption of neurotransmitters, as well as certain predicted neuroactive bacteria metabolites (e.g. short-chain fatty acids, γ-aminobutyric acid, peanut trenium and phosphorus.lead recommendation szxA previous randomized double-blind placebo-controlled trial showed that supplementing plant lactobacillus P-8 may relieve stress and anxiety in adults. An in-depth analysis of the results of a new study published in Neurobiology of Stress by Zhang Peace team at Inner Mongolia Agricultural University found that plant Lactobacillus P-8 regulates the diversity and composition of the intestinal flora, increases the pathogen synthesis/consumption-related paths of neurotransmitters in the intestinal flora, and is rich in potential neuroactive flora metabolites.Neurobiology of stress.IF:7.197Probiotic consumption relieved human stress and anxiety symptoms so that mayy via modulating the neuroactive potential of the gut microbiotaintake probiotics can be alleviated by regulating the potential neurostatic effects of the gut microbiota Stress and anxiety symptoms 10.1016/j.ynstr.2021.100294 01-12, Article Abstract: Put away
Stress has been shown to disturb the balance of human intestinal microbiota and subsequently causes mental health problems like anxiety and depression. Our previous study showed that ingesting the probiotic strain, Lactobacillus (L.) plantarum P-8, for 12 weeks could alleviate stress and anxiety of stressed adults. The current study was a follow-up work aiming to investigate the functional role of the gut metagenomes in the observed beneficial effects. The fecal metagenomes of the probiotic (n = 43) and placebo (n = 36) receivers were analyzed in depth. The gut microbiomes of the placebo group at weeks 0 and 12 showed a significantly greater Aitchison distance (P < 0.001) compared with the probiotic group. Meanwhile, the Shannon diversity index of the placebo group (P < 0.05) but not the probiotic group decreased significantly at week 12. Additionally, significantly more species-level genome bins (SGBs) of Bifidobacterium adolescentis, Bifidobacterium longum, and Fecalibacterium prausnitzii (P < 0.01) were identified in the fecal metagenomes of the probiotic group, while the abundances of SGBs representing the species Roseburia faecis and Fusicatenibacter saccharivorans decreased significantly (P < 0.05). Furthermore, the 12-week probiotic supplementation enhanced the diversity of neurotransmitter-synthesizing/consuming SGBs and the levels of some predicted microbial neuroactive metabolites (e.g., short-chain fatty acids, gamma-aminobutyric acid, arachidonic acid, and sphingomyelin). Our results showed a potential link between probiotic-induced gut microbiota modulation and stress/anxiety alleviation in stressed adults, supporting that the gut-brain axis was involved in relieving stress-related symptoms. The beneficial effect relied not only on microbial diversity changes but more importantly gut metagenome modulations at the SGB and functional gene levels.First Authors:
Teng Ma,Hao Jin Correspondence Authors:
Heping Zhang All Authors:
Teng Ma,Hao Jin,Lai-Yu Kwok,Zhihong Sun,Min-Tze Liong,Heping Zhang