Zheng Junke's research group from Shanghai Jiaotong University School of Basic Medicine published new results in Blood that bone marrow microenvironment components maintain the stemness of hematopoietic stem cells

Recently, the research group of researcher Zheng Junke from the School of Basic Medicine published a research paper entitled "Endothelial cell-derived angiopoietin-like protein 2 supports hematopoietic stem cell activities in bone marrow niches" online in Blood, an internationally renowned journal in the field of blood

Hematopoietic stem cells (HSCs) have the ability to self-renew and differentiate into all hematopoietic cells, and are one of the important adult stem cells that maintain the normal life functions of humans

This study specifically knocked out the expression of angiopoietin-like protein 2 (Angptl2) in mouse Niche endothelial cells, mesenchymal stem cells, and megakaryocytes, confirming that only ANGPTL2 derived from vascular endothelial cells can maintain HSCs Self-renewal ability

Diagram of the working mode of ANGPTL2 derived from endothelial cells in bone marrow microenvironment regulating the stemness of HSCs

Researcher Yu Zhuo from the Department of Pathophysiology of School of Basic Medical Sciences and PhD student Yang Wenqian are the co-corresponding authors of this paper