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Zhou Bin's group reveals the differentiation potential of adult Sca1+ endothelial progenitor cells

 Last Update: 2021-10-20
 Source: Internet
 Author: User

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Changes in the structure and function of blood vessels can cause pathological changes such as decreased elasticity of blood vessel walls and stenosis of the lumen, which can lead to cardiovascular diseases such as coronary heart disease and hypertension

In order to systematically study the fate of adult Sca1 ⁺ endothelial progenitor cells under normal physiology and injury, the researchers established a lineage tracing system that specifically labeled Sca1 ⁺ vascular endothelial cells, the anti-estrogen drug tamoxifen (tamoxifen) After induction treatment, it was found that Sca1-2A-CreER;R26-GFP mice could specifically label some vascular endothelial cells

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Figure: Sca1 ⁺ endothelial progenitor cells can differentiate into endothelial cells in aortic stenosis-induced fibrosis model (a) and femoral artery injury model (b).

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