Zou Yuandong innovates "enzymatic peptide"

Zou Yuandong's character is that he likes to work and drill "If I only thought about personal gold, I might have been a multimillionaire." In Zou Yuandong's mind, the patent of "enzymatic polypeptide" first belongs to China   ■ news origin   Human peptide research has a history of more than 100 years So far, at least four research achievements have won the Nobel Prize However, there are still no researches on "simulating human synthetic peptide model to synthesize peptide in vitro" and "biocatalytic protein degradation technology" Zou Yuandong, 56, has filled in this gap after nearly ten years of hard work His "enzymatic peptide" has become a "hot spot" in the world peptide industry His "enzymatic polypeptide" has set a new world record in molecular weight distribution, amino acid composition, "no bitterness", green property, detection technology and other aspects, and won the first place in the world for China in this field   Recently, if you input "Zou Yuandong" into Google search, you will get 4730 messages; if you input "Baidu", you will get 260300 messages Further search will not make it difficult to find people's daily, people's daily (Overseas Edition), Guangming Daily, economic daily, PLA Daily, CCTV, CNR, scientific Chinese, contemporary economy, Xinhua, Renmin, Guangming, China military, CCTV international, Phoenix, Tom, Chinese Academy of Sciences, Chinese diseases More than 2000 media and the Internet, such as the control center, have reported or reproduced the information about peptide scientist Zou Yuandong and his independent innovation of "enzymatic peptide"   The food protein that people usually eat, whether high-quality food protein or high protein, is protein macromolecule, which can not be directly absorbed by the human body It can only be absorbed and utilized by the human body after being degraded into small peptide and amino acid by the human body's enzyme pepsin, pancreatin, digestive enzyme and the acid-base substance of the human body's digestive system The model of peptide synthesis was carried out in vitro Zou Yuandong, a researcher, Professor, senior engineer and first-class senior nutritionist, explained his "enzymatic peptide", which imitates the human synthetic peptide model to synthesize peptides in vitro   For the core competitiveness of enterprises   In 1994, Zou Yuandong resolutely left Shenzhen, the southern coastal city that people yearned for at that time, abandoned the high wage, high-income, comfortable and elegant living environment, took a million yuan loan to Jingchu land to start a business, and established Wuhan jiushengtang Bioengineering Co., Ltd As the "thoroughfare of nine provinces", Hubei has the most complete industry in China How can a small jiushengtang stand here?   Zou Yuandong said to his colleagues, "if you want to stand here and keep a firm foothold, you must find the 'core competitiveness' of an enterprise This competitiveness is that no one has it and no one has it People have their new high-tech products." In order to obtain it, we must have a strategic vision ahead of time before we can seize the commanding heights We can't follow others We can do what others do We can't copy and imitate other people's technology and products We must take our own path, innovate independently and be independent If we want to start our business in Hubei Province, we should work out the advanced technology and products leading the world, so as to make ourselves invincible in the fierce market competition "   Zou Yuandong's eyes are on the international "sunrise industry" - bioengineering technology industry Among the world's biological products, the United States, Japan and Europe account for more than 80% of the market share In terms of the biotechnology industry, Europe and the United States account for 93% of the global biotechnology share, while the United States alone accounts for more than 70%, while the Asia Pacific Region only accounts for 3% China is a big developing country Compared with the bioengineering technology industry in developed countries, there is still much room for development From "Sanjiu manna" to anti-aging "selenium rich Rosa juice", jiushengtang, a "newborn calf", has entered the biotechnology industry "Biology Dictionary", "functional food biotechnology", "Introduction to modern biotechnology", "biochemistry", "protein chemistry and proteomics", "food protein chemistry", "pharmaceutical dictionary" and other heavy "bricks" have become Zou Yuandong's personal belongings for a moment His Falcon like eyes keep searching everywhere   In the early summer of 1995, the words "oral albumin" inadvertently said by a friend crossed his brain like a lightning bolt This is the beginning of Zou Yuandong's journey of science and technology   Devout "learning from the west"   It rained heavily along the way Thunder and lightning chased the car for "bombing" For 19 hours, when driving to Shanghai, people were exhausted and cars were paralyzed After searching for scientific research institutions like comb hair in big Shanghai, we finally found one of the developers in a biological research institute in the remote suburb Zou Yuandong found that this product is a macromolecular protein with low technology content Fortunately, in the conversation, the other side mentioned another word "peptide" Protein macromolecules are broken down into polypeptides by enzymes, but they are only in the laboratory stage, which is called "bioenergy oral liquid" Zou Yuandong is very excited He has been looking for the core competitiveness of the enterprise, paying attention to the forefront of the biological industry, knowing the value of "peptide", and also knowing that the degradation of protein into "peptide" in vitro is the problem that biology in the world is tackling   All living things, from the simplest virus to human beings, are made up of the same 20 amino acids After in-depth study, scientists have found a kind of intermediate substance between amino acids and proteins polypeptides Polypeptides are compounds that are linked by peptide bonds between two or more amino acids After entering the human body, the macromolecular protein must be enzymatic decomposed into peptides and amino acids through the digestive tract before it can be absorbed by the small intestine Small peptides have the dual functions of providing nutrition and regulating physiological functions of the body, which affect almost all metabolism and synthesis of the body Oligopeptides are those with molecular weight less than 1000, polypeptides with molecular weight more than 1000, and macromolecular proteins with molecular weight more than 5000 Small peptides are known as "crowns" in polypeptides because of their strong activity and diversity which are not possessed by macromolecular proteins and amino acids   In the medical field, scientists all over the world have developed many peptides with special physiological and pharmacological characteristics by using gene expression, chemical synthesis and protein synthesis, such as thymosin, interferon, tumor necrosis factor, interleukin, atrial peptide, neuropeptide, etc., and some have developed drugs for clinical use However, there is no substantial breakthrough in the research and development of bioactive peptides In the use of decomposition methods, such as acidolysis, alkali hydrolysis, hydrogenolysis, electrolysis to obtain peptides, the results are very small, the fixed investment is large, the cycle is long, the pollution is serious, and the industrial production has not been realized Soybean polypeptides have been developed by acidolysis in Japan, but the molecular weight is more than 3000, the product has bitter taste, and the flavor is still poor after debittering process, so they are only used as additives in food industry As for the peptide terminal products that can be taken orally directly, there is no report so far   Zou Yuandong, with the keen vision of an entrepreneur, can directly take orally the "peptide", which is the "real classic" of scientific research and exploration, and the "secret collection" of enterprise development   On the shoulders of giants   The laboratory product "bioenergy oral liquid" is a kind of pancreatin extracted from pig pancreas, which can directly decompose the whole egg protein of poultry This works in a small number of laboratory experiments, but there is a problem with industrial production The first is to knock the eggs into the enzymolysis tank in the factory to pollute the workshop The smell is not only unbearable for the operators, but also fishy for ten miles around the factory during enzymolysis, which is totally not in line with the environmental protection; the second is difficult, long time, not easy to filter, low peptide yield, resulting in huge investment and high cost; the third is that the end product protein peptide oral liquid is fishy and hard to swallow   To get peptide out of the ivory tower, we must innovate the formula and technological process independently Zou Yuandong studied the mode and process of protein degradation in human body, and got great enlightenment Can we replace animal enzymes with mild and fragrant plant enzymes? Can the purified and concentrated protein powder replace the whole egg protein solution? In order to prove his idea, Zou Yuandong looked up all the relevant materials he could find On a business trip to Beijing, he accidentally saw a magazine about Food Science in the hotel There was an article about the performance and characteristics of pineapple enzyme, which immediately inspired him Like looking for treasure, he ran a dozen waste recycling stations one after another, picking up a big sack of waste and miscellaneous records in the station, burning the lights all night   When the experts listened to Zou Yuandong's talk about his own technical ideas, they were surprised: This is not the business manager of this major, but the proposal adopted the leading-edge achievements not involved in this major The ideas are as broad as the sky, and the measures are as meticulous as spider weaving!   Zou Yuandong went to Shanghai in person to order equipment and raw materials, and organized a series of approval procedures before putting into production At this critical and most tense time, his wife, who had been in hospital, fell ill Zou Yuandong should not only take time to take care of his wife, but also sit on the production site Together with experts, he will command the installation and commissioning of the equipment, research, small test and improvement, and finally trial produce the "protein peptide" successfully   On November 24, 1997, a brief message from people '   Industry insiders all know that the smaller the molecular weight of peptide, the shorter the "amino acid chain", the more easily absorbed and utilized by human body Small peptides (especially oligopeptides with less than 6 amino acids) enjoy the reputation of "crown" of polypeptides, because they have very strong activity and diversity and play an important biological function in human body, which are not possessed by large peptides Therefore, many peptide experts believe that "enzymatic peptide" marks the first substantial breakthrough in the research of small molecular peptide by Chinese researchers Some experts even think that "enzymatic peptide" represents the level and trend of peptide research, development, production and innovation in the world   The first batch of "Sanjiu protein peptide" of Wuhan jiushengtang "enzymatic peptide" was shipped to Hong Kong directly from the workshop in containers, earning more than 1 million Hong Kong dollars at a time "Sanjiu protein peptide" is a bright spot in the medical insurance Museum of the successive Canton fair since 1997, and also the first transaction project of the first hi tech fair in Shenzhen, China in 1999 At present, the product has been sold to more than 10 countries and regions   Wuhan jiushengtang's peptide products are also on the market,