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Nature Chemical Biology semi-synthetic biosensors reveal intracellular metabolic balance of CoA
Time of Update: 2022-11-14
Xue Lin's research group of the Department of Life Science and Medicine of the University of Science and Technology of China and its collaborator, Professor Kai Johnsson of the Max Planck Institute for Medical Research in Germany, have made important progress in the study of intracellular metabolic processes of coenzyme A (CoA), and the relevant research results are based on " Using Semisynthetic Biosensors to Reveal the Metabolic Balance of CoA," published online in Nature Chemical Biology on October 31.
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Nature Chemical Biology: American scientists have discovered anti-inflammatory molecules that play an important role in brain aging
Time of Update: 2022-11-14
Taken together, this is the first study to show that a class of aging-associated central nervous system lipids exert anti-inflammatory effects, and the findings suggest that the gradual decrease in the content of SGDGs with age leads to neuroinflammation in the elderly brain, which ultimately leads to age-related pathological changes.
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Nature Chemical Biology: Mechanism of action of TRPV3 ion channel protein inhibitors and potential for the treatment of a variety of skin diseases
Time of Update: 2022-11-04
Trpvicin has shown good therapeutic effect in mouse models To further investigate the mechanism by which Trpvicin functions, the authors used cryo-EM to resolve the high-resolution structure of the human-derived TRPV3-Trpvicin complex, revealing that Trpvicin binds to a reported TRPV In the pockets of ligand sites, Trpvicin was found to exert inhibition by stabilizing TRPV3 in the off state.
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Another important result: Bang Yao Biologics Nature Chemical Biology publishes a paper to develop a precise and safe new adenine base editor -- "ABE9"
Time of Update: 2022-10-31
Base editing technology was first developed by David R. Liu's team at Harvard University, and is mainly divided into two categories: cytosine base editor (CBE) and adenine base editor (ABE), which ar
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Nature Chemical Biology: How Stressful Tumor Cells Escape Cell Death
Time of Update: 2022-10-02
1038/s41589-022-01145-w When free radicals get out of control and disrupt protective cell membranes in a chain reaction, cells die of iron death (Ferroptosis).
1038/s41589-022-01145-w When free radicals get out of control and disrupt protective cell membranes in a chain reaction, cells die of iron death (Ferroptosis).
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Nature Chemical Biology: Crazy Idea: Arming CAR-T Cells to Become a 'Micro Pharmacy' for Cancer Drugs
Time of Update: 2022-01-23
Scheinberg, corresponding author of the study, said: "We call the engineered cells SEAKER cells, SEAKER stands for Synthetic Enzyme-Armed KillER cells, which not only enhance the targeting ability of CAR-T cells, but also combine local Effective small molecule anticancer drugs minimize accidental injury and achieve dual effects .
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Liu Tao's team published an insulin-secreting cell therapy system regulated by unnatural amino acids in "Nature Chemical Biology"
Time of Update: 2022-01-23
In response to this problem, Liu Tao's team has developed a non-natural amino acid-regulated insulin cell therapy system ( Noncanonical Amino acids (ncAAs)-triggered Therapeutic Switch, NATS ) using gene codon expansion technology , which bypasses transcriptional regulation and directly regulates proteins at the translational level.
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Nature Chemical Biology Yi Chengqi research group develops double-pegRNA-mediated high-efficiency guided editing
Time of Update: 2021-11-15
On October 28, 2021, the Peking University School of Life Sciences and the Peking University-Tsinghua Life Sciences Joint Center Yi Chengqi research group published a research paper entitled "Increasing the efficiency and precision of prime editing with guide RNA pairs" in Nature Chemical Biology.
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On November 1, 2021, Ren Aiming's laboratory published a paper in Nature Chemical Biology to reveal
Time of Update: 2021-11-14
On November 1 , 2021 , Ren Aiming's research group at Zhejiang University and Yang Yi's research group from East China University of Science and Technology jointly published a research paper entitled "Structure-based investigation of fluorogenic Pepper aptamer" in Nature Chemical Biology , reporting a new type of RNA fluorescence aptamer.
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Nature Chemical Biology: using protein array to develop spindlin 1 small molecule inhibitor
Time of Update: 2017-08-09
Histone modification is one of the basic mechanisms of epigenetic regulation, which is considered to constitute a kind of "histone code", regulating the organization and interpretation of genetic info
