2021 China's top ten progress in life science announced that artificial synthetic starch was selected

China Youth Daily Client News (China Youth Daily, China Youth Daily reporter Qiu Chenhui) For the first time, carbon dioxide was used to artificially synthesize starch, and the complete composition of the new coronavirus transcription and replication machine was discovered and reconstructed for the first time.

The selection of the "Top Ten Progress in China's Life Science" has been carried out by the China Association for Science and Technology Life Science Society Consortium since 2015.

According to the introduction from the Life Science Society of China Association for Science and Technology, in 2021, the Tianjin Institute of Industrial Biotechnology of the Chinese Academy of Sciences and the Dalian Institute of Chemistry and other units will realize the artificial total synthesis of carbon dioxide to starch for the first time in the world, and the energy efficiency and speed will surpass that of corn.

Among the top ten selected progresses, two are related to the fight against the new crown pneumonia epidemic, namely "Research on the Mechanism of Novel Coronavirus Escape from Host Innate Immunity and Antiviral Drugs" and "Cross-species Recognition and Molecular Mechanism of Coronavirus".

Specifically, the research group of Academician Rao Zihe and Professor Lou Zhiyong of Tsinghua University discovered and reconstructed the complete composition of the new coronavirus transcription and replication machinery for the first time in the world, and for the first time clarified the key to the "capped" maturation of the viral messenger RNA Enzyme molecules, they also found for the first time that the virus "removes" mismatched bases and antiviral drugs in a "trans backtracking" manner, elucidating the molecular mechanism of the poor effect of drugs such as remdesivir, in order to optimize the polymerase.

In addition, the genetic innovation mechanism of vertebrate evolution from aquatic to terrestrial, the assembly mechanism of transcription initiation supercomplex, a new mode of high-efficiency and low-toxicity treatment to improve the efficacy of middle-advanced nasopharyngeal carcinoma, the rapid de novo domestication of allotetraploid wild rice, Unraveling the mystery of long-distance bird migration, interferometric single-molecule localization microscopy, whole-brain single neuron diversity research, and informatics big data platform were also selected as the top ten progresses

According to the news from the China Association for Science and Technology Life Science Society Consortium, the selection of the top ten progress in China's life sciences has been carried out for seven consecutive years