A&R: Antibodies to cartilage oligomeric matrix protein (COMP) are pathogenic in mice and may be clinically relevant to rheumatoid arthritis

Objective : Cartilage oligomeric matrix protein (COMP) is an autoantigen in rheumatoid arthritis (RA) and experimental models of arthriti.

Objective Cartilage oligomeric matrix protein (COMP) is an autoantigen in rheumatoid arthritis (RA) and experimental models of arthriti.

Methods We investigated the pathogenicity of monoclonal anti- COMP antibodies in mice using passive transfer experiments and explored the interaction of anti- immune COMP antibodies with cartilage using immunohistochemical stainin.

Results The murine monoclonal anti- COMP antibody 15A11 induced arthritis in naive mi.

Conclusions The findings provide a structural basis for binding pathogenic anti- COMP antibodies to cartila.

Source: Ge,.

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(2022), Antibodies to Cartilage Oligomeric Matrix Protein Are Pathogenic in Mice and May Be Clinically Relevant in Rheumatoid Arthrit.

Arthritis Rheumatol, 74: 961-97https://d.

org/11002/a.

42072 https://d.

org/11002/a.

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