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A&R: CD163+ M2 macrophages promote fibrosis in IgG4-related diseases via Toll-like receptor 7/IL-1 receptor-related kinase 4/NF-κB signaling pathway

 Last Update: 2022-08-11
 Source: Internet
 Author: User

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Objectives: IgG4 - related disease (IgG4-RD) is a fibroinflammatory disease that affects multiple orga.

Methods: Gene expression in SGs from human TLR7 transgenic mice and IgG4-RD patients was analyzed using DNA microarray.

Results: IRAK3 and IRAK4 were significantly overexpressed in TLR7 transgenic mice and IgG4-RD patient.

CD163+ M2 macrophages promote fibrosis in IgG4-RD by increasing fibrotic cytokine production through TLR-7/IRAK4/NF - κB signalin.

Source: Chinju,.

Chinju,.
, Moriyama,.
, Kakizoe-Ishiguro, et .
(2022), CD163+ M2 Macrophages Promote Fibrosis in IgG4-Related Disease Via Toll-like Receptor 7/Interleukin-1 Receptor–Associated Kinase 4/NF-κB Signali.
Arthritis Rheumatol, 74: 892-90https://d.
org/11002/a.
42043 https://d.
org/11002/a.
42043Comment here

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