A&R: Estrogen-induced hsa-miR-10b-5p is elevated in T cells of patients with systemic lupus erythematosus and down-regulates the serine/arginine-rich splicing factor 1

Background / purpose : their immune effects of disease on women is larger than the impact on men
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Estrogen is related to immune cell dysfunction, but its precise molecular role is not fully understood

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Backgroundbackground / / Objective Objective : their immune effects of disease on women is larger than the impact on men

Method : SRSF1 -3'-the UTR of bioinformatics analysis indicated a plurality of microRNA ( miRNAs ; of miR ) binding site

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MethodMethod : SRSF1 SRSF1 -3'-the UTR of Bioinformatics analysis revealed plurality Bioinformatics of microRNA ( miRNAs ; of miR ) binding site
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Resultsresults : studies have shown that estrogen increases the human T cells, hsa-miR-10b-5p expression, and hsa-miR-10b-5p cut SRSF1 protein expression
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ConclusionConclusion : This study found a molecular link between estrogen and previously unrecognized gene regulation in immune cells, may be associated with systemic autoimmune diseases
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Source:

Ramanujan, SA, Cravens, EN, Krishfield, SM, Kyttaris, VC and Moulton, VR (2021), Estrogen-Induced hsa-miR-10b-5p Is Elevated in T Cells From Patients With Systemic Lupus Erythematosus and Down-Regulates Serine/ Arginine-Rich Splicing Factor 1.
Arthritis Rheumatol, 73: 2052-2058.
  https://doi.
org/10.

1002/art.
41787

Ramanujan, SA, Cravens, EN, Krishfield, SM, Kyttaris, VC and Moulton, VR (2021), Estrogen-Induced hsa-miR-10b-5p Is Elevated in T Cells From Patients With Systemic Lupus Erythematosus and Down-Regulates Serine/ Arginine-Rich Splicing Factor 1.
Arthritis Rheumatol, 73: 2052-2058.
  https://doi.
org/10.
1002/art.
41787 https://doi.
org/10.

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