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A&R: Extramucosal formation and prognostic value of secreted antibodies in rheumatoid arthritis

 Last Update: 2022-08-11
 Source: Internet
 Author: User

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Objectives: Recent advances suggest that mucosal surfaces are important early in the development of rheumatoid arthritis (RA), especially in anti-citrullinated protein antibody (ACPA)-positive disea.

Rheumatoid Arthritis Studies in RA include levels of secreted Ig including ACPA and possible extramucosal formati.

Three patient groups were studied: 1) ACPA -positive patients with musculoskeletal pain but no clinical arthritis, 2) patients with new-onset RA , and 3) patients with established R.

RESULTS: Compared with healthy controls, serum levels of total secreted IgA and total secreted IgM were increased in both early RA patients and high-risk patients ( P < 05 .

Conclusion: Circulating secretory Ig is elevated before and during the onset of R.

Source: Martinsson,.

Martinsson,.
, Kling, LL, Roos-Ljungberg,.
, Griazeva,.
, Samoylovich,.
, Paul,.
, Rönnelid,.
, Weitoft,.
, Wetterö,.
and Kastbom,.
(2022), Extramucosal Formation and Prognostic Value of Secretory Antibodies in Rheumatoid Arthrit.
Arthritis Rheumatol, 74: 801-80https://d.

org/11002/a.

42044 https://d.

org/11002/a.

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