A&R: Identification of shared and Asia-specific loci in systemic lupus erythematosus and evidence for a role for type III interferon signaling and lysosomal function in this disease: a multi-ancestry genome-wide association study

Objective: Systemic lupus erythematosus (SLE) is a typical autoimmune disease with differences in prevalence and severity in different ancestral grou.

Objective: Systemic lupus erythematosus (SLE) is a typical autoimmune disease with differences in prevalence and severity in different ancestral grou.

Methods: A cross-ancestry and ancestry-specific meta-analysis was performed for Genome-Wide Association Studies (GWAS) of SLE , involving 30,604 participants from Europe, China, or Thailan.

RESULTS: A 1-bp deletion upstream of IFNLR1 IFNLR1 was found to be associated with SLE , and the risk allele was associated with increased IFNLR1 IFNLR1 expressio.

In this study, shared and Asia-specific sites for SLE were identified, and functional annotation provided evidence for increased type III IFN signaling and decreased SLE lysosomal functional involvemen.

 

Source: Wang,.

Wang,.
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, Zheng,.
, Lei,.
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, Qian,.
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, Mahasirimongkol,.

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, Lau, YL, Zhang,.

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(2022), Identification of Shared and Asian-Specific Loci for Systemic Lupus Erythematosus and Evidence for Roles of Type III Interferon Signaling and Lysosomal Function in the Disease: A Multi-Ancestral Genome-Wide Association Stu.

Arthritis Rheumatol, 74: 840-84https:/ /d.

org/11002/a.

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