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A&R: Rheumatoid factor and anti-modified protein antibody reactivity converge on IgG epitopes

 Last Update: 2022-08-16
 Source: Internet
 Author: User

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Objectives : Patients with rheumatoid arthritis (RA) commonly develop rheumatoid factors (RFs) , IgG Fc -binding antibodies, and anti-modified protein antibodies (AMP.

Objectives Objective : Patients with rheumatoid arthritis (RA) usually produce rheumatoid factors (RFs) , IgG Fc -binding antibodies and anti-modified protein antibodies (AMP.

Methods : Using sera from patients with RA , systemic lupus erythematosus, Sjogren's disease (SjD), or spondyloarthropathy, IgG versus native, citrulline- and homocitrulline-containing IgG constant region linear epitopes were assessed by peptide arr.

Methods Methods : Using sera from patients with RA , systemic lupus erythematosus, Sjogren's disease (SjD), or spondyloarthropathy, IgG versus native, citrulline- and homocitrulline-containing IgG constant region linear epitopes were assessed by peptide array Binding to highly bound epitopes was further assessed by enzyme-linked immunosorbent assay ( ELISA .

Results Results : The research team used high-density peptide arrays and serum to quantify the binding of IgG to linear peptides of every 12 amino acids derived from the constant regions of human IgG1-4 heavy chain.

Conclusions Conclusion : The epitope pool bound by AMPA includes modified IgG epitopes that localize IgG as a common antigen linking the differential reactivity of RF and AMP.

In : Mergaert, AM, Zheng,.
, Denny, MF, Amjadi, MF, Bashar, SJ, Newton, MA, Malmström,.
, Grönwall,.
, McCoy, SS and Shelef, MA (2022), Rheumatoid Factor and Anti–Modified Protein Antibody Reactivities Converge on IgG Epitop.
Arthritis Rheumatol, 74: 984-99https://d.
org/11002/a.
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