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A&R: Rituximab impairs B-cell responses, but not T-cell responses to COVID-19 vaccine in autoimmune disease

 Last Update: 2022-08-16
 Source: Internet
 Author: User

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OBJECTIVE : It has been demonstrated that patients receiving rituximab (RTX) have attenuated antibody responses to the messenger RNA (mRNA) COVID-19 vaccin.

Objectives : It has been demonstrated that patients receiving rituximab (RTX) have attenuated antibody responses to the messenger RNA (mRNA) COVID-19 vaccin.

Methods : We performed anti-Spike IgG assays and neutralization experiments before and 28 days after the second BNT162b2 ( Pfizer -BioNTech) vaccinatio.

Methods We performed anti-Spike IgG assays and neutralization experiments before and 28 days after the second BNT162b2 ( Pfizer -BioNTech) vaccinatio.

Results Compared with other immunosuppressive groups ( 80% ; n=35 ) ( P=0001 ) and healthy controls ( 92% ; n=26) (P<0001) , vaccine neutralizing antibodies were observed in the RTX group The proportion of respondents was lower (29%; n = 2

CONCLUSIONS: RTX induces attenuated antibody responses to mRNA COVID-19 vaccines, but no changes in functional T- cell responses compared with healthy controls and autoimmune disease patients treated with other immunosuppressive agent.

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(2022), Rituximab Impairs B Cell Response But Not T Cell Response to COVID-19 Vaccine in Autoimmune Diseas.

Arthritis Rheumatol, 74: 927-93https://d.

org/11002/a.

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