Acta Haematol: Serum ferritin threshold differentiates patients at higher risk of increased platelets during treatment with hypoxia-inducible factor prolyl hydroxylase domain inhibitors

Hypoxia-inducible factor prolyl hydroxylase domain inhibitor (HIF-PHI) is a new approach for the treatment of renal anemia
.

HIF-PHI is thought to increase iron usage to improve the availability of iron for erythropoiesis

Hypoxia-inducible factor prolyl hydroxylase domain inhibitor (HIF-PHI) is a new approach for the treatment of renal anemia

Figure 1: Changes in PLT values ​​and iron content levels on day 0
.

Receiver operating characteristic curves for (a)-ft, (b) TSAT, and (c)-Fe for PLT ≤ 0% rate of change

Figure 1: Changes in PLT values ​​and iron content levels on day 0

Figure 2: Changes in PLT over time in low and high s-ft groups and comparisons between groups
.

PLT was significantly increased in the low s-ft group (*;P

Figure 2: Changes in PLT over time in low and high s-ft groups and comparisons between groups

Multivariate analysis showed that PLT rate of change was associated with serum ferritin (s-ft) and red blood cell (RBC) counts [β coefficient; 0.

Table: The relationship between each factor and the rate of change of PLT was analyzed using a linear regression model Table: The relationship between each factor and the rate of change of PLT was analyzed using a linear regression model

Abbreviations: ◁s-Fe; change in serum iron (every 1 μg/dL increase), ◁s-ft; change in serum ferritin (every 1 ng/mL increase), ◁RBC; change in red blood cell count (every 1 × 10 ⁴ /μL increase) ), Rox: Roxda dose (every 1 mg/kg increase), CI; confidence interval

Abbreviations: ◁s-Fe; change in serum iron (every 1 μg/dL increase), ◁s-ft; change in serum ferritin (every 1 ng/mL increase), ◁RBC; change in red blood cell count (every 1 × 10 ⁴ /μL increase) ), Rox: Roxda dose (every 1 mg/kg increase), CI; confidence interval ⁴

Overall, this study shows that changes in PLT are associated with s-ft and hematopoiesis
.

When the s-ft was 77.
2 ng/mL or higher when converting from DA to Rox, there was less likelihood of increased PLT due to iron levels

Original source:

Ogawa C, Tsuchiya K, Tomosugi N, Maeda K.

Ogawa C, Tsuchiya K, Tomosugi N, Maeda K.
Threshold of Serum Ferritin to Discriminate against Those at Greater Risk of Platelet Increase during Treatment with Hypoxia-Inducible Factor Prolyl Hydroxylase Domain Inhibitor.
Acta Haematol.
2022 Jan 20.
doi: 10.
1159/000522071 .
Epub ahead of print.
PMID: 35051929.
Ogawa C, Tsuchiya K, Tomosugi N, Maeda K.
Threshold of Serum Ferritin to Discriminate against Those at Greater Risk of Platelet Increase during Treatment with Hypoxia-Inducible Factor Prolyl Hydroxylase Domain Inhibitor.
Acta Haematol .
2022 Jan 20.
doi: 10.
1159/000522071.
Epub ahead of print.
PMID: 35051929.
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