-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
- Cosmetic Ingredient
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Normally, the blood pressure of healthy people will drop during sleep (the average systolic blood pressure is reduced by ≥10%), which is called "dipper type"
.
If the blood pressure at night is not sufficiently lowered (the mean systolic blood pressure is lowered less than 10%), it is called "non-dipper type"
.
If the patient's night blood pressure does not drop but rises (the average systolic blood pressure decreases <10%), it is called "reverse dipper type"
.
It is understood that the "anti-dipper" blood pressure pattern is associated with an increased risk of cardiovascular complications and death in adults with type 1 or type 2 diabetes
.
Recently, an Italian cohort study published at the American Heart Association's Annual Meeting of Hypertension Science showed that when diabetic patients have irregular blood pressure at night, their long-term survival rate will be reduced
.
Study introduction CHAMP1ON study enrolled 349 patients from Pisa, Italy, of which 284 patients had type 2 diabetes and 64 patients had type 1 diabetes
.
The average age of the participants was 57.
1 years, and the ratio of men to women was roughly the same
.
Patients with hypertension accounted for 82%, and patients with hypertension taking antihypertensive drugs but not yet controlled accounted for 73%
.
At baseline, all patients had blood pressure testing in outpatient clinics and 24h ambulatory blood pressure monitoring (ABPM)
.
According to the results of the study, in the CHAMP1ON cohort, most patients were "dipper type", 40% of patients were "non-dipper type", and 11% were of anti-dipper type
.
With a median follow-up of 21.
0 years, the average survival time of "anti-dipper" patients was 16.
1 years, "non-dipper" patients was 17.
5 years, and "dipper" patients was 18.
6 years
.
This difference still exists after adjusting for blood pressure control and other factors
.
Compared with "non-dipper" patients, the death rate of "anti-dipper" participants almost doubled
.
The mortality of "non-dipper type" patients is similar to that of "dipper type" hypertension patients
.
In addition, patients with a lower 24h heart rate change rate had a shorter overall survival rate, but it was not statistically significant (aHR=1.
2, 95% CI 0.
8-1.
8)
.
The researchers said that Dr.
Chiriacò pointed out that "anti-dipper type" patients are more likely to be elderly and hypertensive patients
.
The prevalence of cardiac autonomic neuropathy, chronic kidney disease and concentric cardiac remodeling is also higher in this group
.
"Non-dipper type" is associated with a high risk of kidney disease and cardiovascular disease in healthy people, as well as high blood pressure and type 1 or type 2 diabetes
.
Low heart rate variability is associated with poor prognosis of patients with heart failure and an increased risk of coronary heart disease in the general population
.
24h ABPM is an ideal tool for diagnosing abnormal blood pressure and heart rate circadian rhythm changes.
It is helpful for the treatment of patients with uncontrolled hypertension at night, such as taking antihypertensive drugs at night instead of morning
.
This randomized study showed that taking antihypertensive drugs at night can help better control blood pressure
.
Other studies have also shown that taking antihypertensive drugs at night can reduce the incidence of diabetes in hypertensive patients
.
In addition, the participants in this study are mainly white, which is very important, so reports of "non-dipper type" are more common among African or Hispanic people
.
Yimaitong compiled from: Nicole Lou, Staff Writer.
More Evidence for Taking Blood Pressure Meds Before Bed—Circadian BP patterns linked to long-term survival in people with diabetes.
MedPage Today.
Nov 3, 2020.
.
If the blood pressure at night is not sufficiently lowered (the mean systolic blood pressure is lowered less than 10%), it is called "non-dipper type"
.
If the patient's night blood pressure does not drop but rises (the average systolic blood pressure decreases <10%), it is called "reverse dipper type"
.
It is understood that the "anti-dipper" blood pressure pattern is associated with an increased risk of cardiovascular complications and death in adults with type 1 or type 2 diabetes
.
Recently, an Italian cohort study published at the American Heart Association's Annual Meeting of Hypertension Science showed that when diabetic patients have irregular blood pressure at night, their long-term survival rate will be reduced
.
Study introduction CHAMP1ON study enrolled 349 patients from Pisa, Italy, of which 284 patients had type 2 diabetes and 64 patients had type 1 diabetes
.
The average age of the participants was 57.
1 years, and the ratio of men to women was roughly the same
.
Patients with hypertension accounted for 82%, and patients with hypertension taking antihypertensive drugs but not yet controlled accounted for 73%
.
At baseline, all patients had blood pressure testing in outpatient clinics and 24h ambulatory blood pressure monitoring (ABPM)
.
According to the results of the study, in the CHAMP1ON cohort, most patients were "dipper type", 40% of patients were "non-dipper type", and 11% were of anti-dipper type
.
With a median follow-up of 21.
0 years, the average survival time of "anti-dipper" patients was 16.
1 years, "non-dipper" patients was 17.
5 years, and "dipper" patients was 18.
6 years
.
This difference still exists after adjusting for blood pressure control and other factors
.
Compared with "non-dipper" patients, the death rate of "anti-dipper" participants almost doubled
.
The mortality of "non-dipper type" patients is similar to that of "dipper type" hypertension patients
.
In addition, patients with a lower 24h heart rate change rate had a shorter overall survival rate, but it was not statistically significant (aHR=1.
2, 95% CI 0.
8-1.
8)
.
The researchers said that Dr.
Chiriacò pointed out that "anti-dipper type" patients are more likely to be elderly and hypertensive patients
.
The prevalence of cardiac autonomic neuropathy, chronic kidney disease and concentric cardiac remodeling is also higher in this group
.
"Non-dipper type" is associated with a high risk of kidney disease and cardiovascular disease in healthy people, as well as high blood pressure and type 1 or type 2 diabetes
.
Low heart rate variability is associated with poor prognosis of patients with heart failure and an increased risk of coronary heart disease in the general population
.
24h ABPM is an ideal tool for diagnosing abnormal blood pressure and heart rate circadian rhythm changes.
It is helpful for the treatment of patients with uncontrolled hypertension at night, such as taking antihypertensive drugs at night instead of morning
.
This randomized study showed that taking antihypertensive drugs at night can help better control blood pressure
.
Other studies have also shown that taking antihypertensive drugs at night can reduce the incidence of diabetes in hypertensive patients
.
In addition, the participants in this study are mainly white, which is very important, so reports of "non-dipper type" are more common among African or Hispanic people
.
Yimaitong compiled from: Nicole Lou, Staff Writer.
More Evidence for Taking Blood Pressure Meds Before Bed—Circadian BP patterns linked to long-term survival in people with diabetes.
MedPage Today.
Nov 3, 2020.
