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Background: Diabetes mellitus (DM) is a common chronic disease whose prevalence continues to rise
.
As diabetes progresses, neuropathy has become the most common complication in diabetic patients
Neuropathy has become the most common complication in diabetic patients
A total of 22 DON patients and 22 healthy controls were enrolled
.
The DALFF method was used in all participants to investigate differences in dynamic intrinsic brain activity between the two groups
Results: Compared with the HCS group, the DALFF variability of the right middle frontal gyrus in the DON group was significantly increased (P<0.
01)
.
In contrast, DALFF variability in the right precuneus was significantly lower in DON patients (P<0.
Figure 1 A case of diabetic optic neuropathy, fundus photography (A) and fluorescein angiography (B)
.
Perioptic hemorrhage (red arrow) and optic disc edema (white arrow) were observed
Figure 1 A case of diabetic optic neuropathy, fundus photography (A) and fluorescein angiography (B)
Table 1
.
Clinical characteristics of the participants in this study
Table 1
Figure 2.
Comparison of different dALF values between DON patients and HCS patients
.
The spatial distribution pattern of dALFF variation in DON patients was observed
Figure 2.
Table 2.
Brain regions with significantly different dALFF values between DON and HCS patients
Brain regions with significantly different dALFF values between DON and HCS patients
Figure 3.
ROC curve analysis of mean dALFF values for altered brain regions
.
(B) DON
ROC curve analysis of mean dALFF values for altered brain regions
.
(B) DON
Figure 4
.
Correlation of dALFF values of MFG_R with clinical behavior
.
Pearson correlation analysis was used to determine a significant linear relationship between dALF values and HDS scores
.
The anxiety score was negatively correlated with the DALFF value of MFG_R (r=−0.
6406, P<0.
0 1), and the depression score was negatively correlated with the DALF value of MFG_R (r=−0.
6346, P<0.
0 1)
.
Abbreviations: dALFF, dynamic amplitude of low-frequency fluctuations; MFG, middle frontal gyrus; R, right; AS, anxiety score; DS, depression score
.
.
Correlation of dALFF values of MFG_R with clinical behavior
.
Pearson correlation analysis was used to determine a significant linear relationship between dALF values and HDS scores
.
The anxiety score was negatively correlated with the DALFF value of MFG_R (r=−0.
6406, P<0.
0 1), and the depression score was negatively correlated with the DALF value of MFG_R (r=−0.
6346, P<0.
0 1)
.
Abbreviations: dALFF, dynamic amplitude of low-frequency fluctuations; MFG, middle frontal gyrus; R, right; AS, anxiety score; DS, depression score
.
Figure 5.
Relationship between dalff value and emotional state in the right middle frontal gyrus
.
Compared with HCS, DON patients had lower dALFF values in the right middle frontal gyrus, and were more prone to anxiety and depression
.
Abbreviations: dALFF, dynamic amplitude of low-frequency fluctuations; HCS, healthy control group; DON, diabetic optic neuropathy
.
Relationship between dalff value and emotional state in the right middle frontal gyrus
.
Compared with HCS, DON patients had lower dALFF values in the right middle frontal gyrus, and were more prone to anxiety and depression
.
Abbreviations: dALFF, dynamic amplitude of low-frequency fluctuations; HCS, healthy control group; DON, diabetic optic neuropathy
.
Conclusion: Abnormal variation of DALFF was observed in a specific area of the brain of DON patients, which is helpful to distinguish DON from HCS and improve the understanding of DON.
High signal intensity in the right middle frontal gyrus may be a potential indicator for the diagnosis of DON
.
The right middle frontal gyrus hyperintensity may be a potential indicator for the diagnosis of DON
.
Source: Yang L, Xiao A, Li QY, et al.
Hyperintensities of middle frontal gyrus in patients with diabetic optic neuropathy: a dynamic amplitude of low-frequency fluctuation study .
Aging (Albany NY) 2022 Feb 04;14