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    Home > Active Ingredient News > Blood System > AJH: Comparison of the incidence of second primary malignancies in treated and untreated patients with chronic lymphocytic leukemia

    AJH: Comparison of the incidence of second primary malignancies in treated and untreated patients with chronic lymphocytic leukemia

    • Last Update: 2021-10-20
    • Source: Internet
    • Author: User
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    With the introduction of targeted drugs into the treatment paradigm of chronic lymphocytic leukemia (CLL), the prognosis of patients has been significantly improved


    With the introduction of targeted drugs into the treatment paradigm of chronic lymphocytic leukemia (CLL), the prognosis of patients has been significantly improved


     

    In this analysis, 1303 patients with recorded CLL diagnoses between 2013 and 2018 were included


    1303 patients with recorded CLL diagnoses from 2013 to 2018 were included


    Although the previous comorbidities and ECOG status of patients in the treatment group and the untreated group were similar, the proportion of advanced patients with del (17p), unmutated IGHV and Binet was higher in the treatment group


    But in the treatment group, the incidence of all SPM, especially hematology SPM, was higher than expected


    In this analysis, they found that the incidence of SPM among treated CLL patients was 42% higher than that of the general population.


    The incidence of SPM in treated CLL patients was 42% higher than that in the general population, mainly because the incidence of hematological SPM was higher than expected, while untreated CLL patients did not have an increased risk of SPM compared with the general population


    Original source:

    Original source:

    Fürstenau, M.


    Fürstenau, M.
    , Giza, A.
    , Stumpf, T.
    , Robrecht, S.
    , Maurer, C.
    , Linde, H.
    , Jacobasch, L.
    , Dörfel, S.
    , Aldaoud, A.
    , von Tresckow, J.
    , Koenigsmann, M.
    , Gaska, T.
    , Kaiser, U.
    , Harich, H.
    -D.
    , Fischer, K.
    , Eichhorst, B.
    , Hallek, M.
    and Fink, A.
    -M.
    (2021), Second primary malignancies in treated and untreated patients with chronic lymphocytic leukemia.
    Am J Hematol.
    Accepted Author Manuscript.
      https://doi.
    org/10.
    1002/ajh.
    26363

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