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    Home > Active Ingredient News > Blood System > AJH: Eltrombopag in the treatment of patients with persistent thrombocytopenia after haploid peripheral blood stem cell transplantation

    AJH: Eltrombopag in the treatment of patients with persistent thrombocytopenia after haploid peripheral blood stem cell transplantation

    • Last Update: 2021-12-01
    • Source: Internet
    • Author: User
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    Persistent thrombocytopenia (PT) is a common complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT), which has a significant negative impact on survival


    Persistent thrombocytopenia (PT) is a common complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT), which has a significant negative impact on survival


    Here, a foreign research team conducted a retrospective study to evaluate the efficacy and safety of Eltrombopag (EPAG) in 34 patients with PT after allogeneic hematopoietic stem cell transplantation


    Here, a foreign research team conducted a retrospective study to evaluate the efficacy and safety of Eltrombopag (EPAG) in 34 patients with PT after allogeneic hematopoietic stem cell transplantation


    Seven patients had long-term solitary thrombocytopenia (PIT), and 27 patients experienced secondary platelet recovery failure (SFPR)


    Figure 1: a, the cumulative incidence of overall remission (72.


    Figure 2: Median platelet count after drug withdrawal and one month after drug withdrawal (P=0.


    Figure 2: Median platelet count (P=0.


    The cumulative incidence (CI) of platelets without transfusion support to at least 20×109×/L and 50×109/L were 72.


    The cumulative incidence (CI) of platelets without transfusion support to at least 20×109×/L and 50×109/L were 72.


    Figure 3: a, the cumulative incidence of total remission (P=0.




    Original source:

    Yan, F.


    Yan, F.
    , Lu, N.
    , Gu, Z.
    et al.
    Eltrombopag in the treatment of patients with persistent thrombocytopenia after haploidentical peripheral blood stem cell transplantation: a single-center experience.
    Ann Hematol(2021).
    https:// doi.
    org/10.
    1007/s00277-021-04706-6

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