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AJH: Hyperoxia-affinity hemoglobinopathies-associated polycythemia: 41 cases of clinical outcome and treatment impact

 Last Update: 2021-10-19
 Source: Internet
 Author: User

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The HOA hemoglobin variant was first described by Virgil Fairbanks in 1971

HOA hemoglobin variant HOA hemoglobin variant thrombosis management

A foreign expert team tried to clarify these issues by studying current characteristics, treatment strategies and follow-up events.

During the 10-year median follow-up, 23 (56%) patients reported one or more symptoms that were thought to be related to elevated Hct, and 10 (24%) patients recorded thrombosis

In summary, the current research does not imply that Hgb/Hct levels are the main contributor to the incidence of HOA hemoglobinopathies-associated polycythemia, and indicates that the value of bloodletting therapy is limited

The current research does not imply that Hgb/Hct levels are the main contributor to the incidence of HOA hemoglobinopathies-associated polycythemia, and indicates that the value of bloodletting therapy is limited

Original source:

Gangat N, Oliveira JL, Hoyer JD, Patnaik MM, Pardanani A, Tefferi A.

Gangat N, Oliveira JL, Hoyer JD, Patnaik MM, Pardanani A, Tefferi A.
High-oxygen-affinity hemoglobinopathy-associated erythrocytosis: clinical outcomes and impact of therapy in 41 cases.
Am J Hematol.
2021 Oct 11.
doi: 10.
1002/ ajh.
26375.
Epub ahead of print.
PMID: 34633117.

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