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Iron overload (IO) is a pathological condition caused by iron accumulation exceeding physiological requirements, which ultimately leads to oxidative damage to important functions
Iron overload (IO) Non-transferrin bound iron (NTBI) has been classically used to represent potentially toxic plasma components detected in whole body iron overload, and is associated with end-organ iron accumulation and biological damage Related
The "total" NTBI detected in plasma provides a measure of IO, while potentially toxic or unstable components have been detected by LPI testing
So far, the main clinical contribution of the labile-NTBI test is to design a treatment plan that aims to reduce tissue exposure to plasma NTBI components (such as LPI), thereby providing a wide range of protection from the impact of the upcoming IO
So far, the main clinical contribution of the labile-NTBI test is to design a treatment plan that aims to reduce tissue exposure to plasma NTBI components (such as LPI), thereby providing a wide range of protection from the impact of the upcoming IO
cholesterol
Original source:
Cabantchik, IZ and Hershko, C.
Cabantchik, IZ and Hershko, C.
(2021), PLASMA NON TRANSFERRIN BOUND IRON- NTBI REVISITED Implications for systemic iron overload and in iv iron supplementation.
Am J Hematol.
Accepted Author Manuscript.
https://doi.
org/10.
1002/ajh .
26374
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