AJKD: Serum levels of polyubiquitinated PTEN in American Indians with type 2 diabetes are associated with decreased renal function

Fibrosis is a major factor in progressive chronic kidney disease (CKD), regardless of its etiology
.

Therefore, the mechanism supporting the occurrence of fibrosis is very important to understand the pathophysiological mechanism of CKD, and fibrosis markers may also be clinical biomarkers of CKD progression

^K27Polyub

Method: This is an observational cohort study
.

Included are Indians (154 women, 80 men) living in the Southwestern United States who are suffering from or at high risk of diabetic nephropathy (DKD)

Results: At baseline, the mean age was 42.
8±10.
5 (SD) years, the history of diabetes was 11.
5±7.
1 years, the mean arterial pressure was 90.
5±9.
5 mmHg, glycosylated hemoglobin 9.
3±2.
4%, GFR 152±45 ml/min, albumin : The median of the creatinine ratio is 38 mg/g (interquartile range 14-215)
.

64 (27.

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Table 1 The relationship between PTEN ^K27Polyub concentration and renal outcome and all-cause mortality

Table 1 The relationship between PTEN ^K27Polyub concentration and renal outcome and all-cause mortality ^K27Polyub

Table 2 The relationship between kidney morphometry and serum PTEN ^K27Polyub

Table 2 The relationship between kidney morphometry and serum PTEN ^{K27Polyub K27Polyub}

Figure 1 Distribution of K27 polyubiquitinated PTEN; A.
^Unconverted B.
Log conversion (The x-axis unit is inverse log, indicating the actual level of serum PTEN ^K27Polyub )

Figure 1 Distribution of K27 polyubiquitinated PTEN; A.
^Unconverted B.
Log conversion (The x-axis unit is inverse log, indicating the actual level of serum PTEN ^K27Polyub ) ^K27Polyub

Figure 2 The survival chart of serum PTEN ^K27Polyub quartile predicting renal prognosis; A.
Renal failure ≥ 40% decrease B.
Renal failure C.
End-stage renal disease or death from any cause

Figure 2 The survival chart of serum PTEN ^K27Polyub quartile predicting renal prognosis; A.
Renal failure ≥ 40% decrease B.
Renal failure C.
End-stage renal disease or death from any cause ^K27Polyub

Conclusion: Among American Indians with type 2 diabetes, higher serum PTEN ^{K27Polyub is} associated with decreased GFR and increased risk of renal failure
.

Among American Indians with type 2 diabetes, higher serum PTEN ^{K27Polyub is} associated with decreased GFR and increased risk of kidney failure
.

^K27Polyub

Original source:

Looker HC, Lin C, Nair V,et al, Serum Level of Polyubiquitinated PTEN and Loss of Kidney Function in American Indians With Type 2 Diabetes.

Serum Level of Polyubiquitinated PTEN and Loss of Kidney Function in American Indians With Type 2 Diabetes.
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